细胞周期蛋白D1
车站3
神经干细胞
芒果藤黄
STAT蛋白
细胞生物学
细胞生长
祖细胞
干细胞
生物
化学
信号转导
细胞周期
细胞
生物化学
医学
传统医学
作者
Xiaohong Yang,Shengnan Wang,Ying Ouyang,Yalin Tu,Anmin Liu,Yinghong Tian,Ming‐Liang He,Rongbiao Pi
标识
DOI:10.1016/j.neulet.2016.05.012
摘要
Garcinia mangostana L. (Mangosteen) has been used to treat various pathological conditions, including inflammation and urinary tract infections. Here, we observed that garcinone D, a natural xanthone from mangosteen, promoted the proliferation of C17.2 neural progenitor cells and also resulted in a larger percentage of cells in S phase compared with the control group. Moreover, garcinone D increased the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and Cyclin D1 in concentration- and time- dependent manners. Garcinone D also increased the protein levels of nuclear factor erythroid 2-related factor (Nrf2) and heme oxygenase-1 (HO-1) in concentration- and time- dependent manners, and inhibiting Nrf2 activation by brusatol could partly reverse garcinone D-induced C17.2 cell proliferation. Taken together, it is the first time to show that garcinone D promotes the proliferation of C17.2 neural stem cells, which may involve the STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. It would provide new inspiration to develop garcinone D as a lead compound to promote the proliferation of endogenous neural stem cells (NSCs).
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