超临界流体色谱法
化学
对映体
色谱法
超临界流体
高效液相色谱法
组合化学
有机化学
作者
Gioacchino Luca Losacco,Jimmy O. DaSilva,Imad A. Haidar Ahmad,Ian Mangion,Terry A. Berger,Erik L. Regalado
标识
DOI:10.1016/j.chroma.2022.463094
摘要
Chiral sub/supercritical fluid chromatography (SFC) has established itself as one of the preferred techniques for enantioseparations at both analytical and preparative scale. Herein, we introduce a parallel multicolumn SFC screening for automated chiral method development in fast-paced settings. The practicality and speed advantages of this approach are illustrated with parallel screening of a diverse set of chiral molecules across ten columns with five different organic modifiers/CO2 based eluents enabling rapid identification of suitable enantioseparation conditions for accelerated purification of pharmaceutical targets. Rapid delivery turnarounds of pure enantiomers of less than 1 h from screening to target isolation are demonstrated illustrating the power of this approach.
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