Diastereoselective synthesis of 1,1,3,3-tetrasubstituted cyclobutanes enabled by cycloaddition of bicyclo[1.1.0]butanes

A diastereoselective cycloaddition of bicyclo[1.1.0]butanes (BCBs) with triazolinedione or nitrosoarenes was developed to access multi-substituted cyclobutanes.