A review towards synthesis of heterocycles using propargyl alcohols and propargyl amines

In the area of drug discovery, nitrogen/oxygen-based heterocycles have been utilized as key intermediates and have great attention in organic chemistry. A literature survey reveals that in the past two decades propargyl alcohols and propargyl amines contributed significantly to the synthesis of such bioactive heterocycles. Propargyl alcohols and propargyl amine precursors are alkyne-based compounds and can be easily converted to propargylic carbocations. The nucleophilic nature of the triple bond and electrophilic nature of furnished carbocations from propargyl alcohols and propargyl amines makes these intermediates highly reactive and useful for the synthesis of various heterocycles by cycloaddition, intermolecular/intramolecular-cyclization, cycloisomerization, cyclo-condensation reactions. Here in this review, we are going to summarize important and useful methodologies for the development of nitrogen and oxygen-based heterocycles using propargyl alcohols and propargyl amines.Graphical abstract