奥马佐单抗
医学
哮喘
免疫球蛋白E
嗜酸性粒细胞
子群分析
荟萃分析
内科学
免疫学
抗体
作者
Yaqin Li,Xiaoyan Li,Biyu Zhang,Qing Yu,Yanming Lu
标识
DOI:10.1080/17476348.2022.2092100
摘要
Predicting omalizumab treatment response has been a challenge and significant aspect for selecting suitable severe allergic asthma patients for omalizumab use.To determine which domains of pretreatment baseline characteristics predict omalizumab treatment response among asthmatic patients.Electronic bases were searched for eligible studies that reported potential biomarkers that could predict omalizumab responsiveness and efficacy. Patients who accepted omalizumab treatment were stratified into responders and non-responders. WMD, OR, and their 95%CI were used to access the differences between those omalizumab receivers. Sensitivity analysis and subgroup analysis were conducted for potential heterogeneity.A total of 41 studies evaluating efficacy predictors of omalizumab were included in this meta-analysis. The pooled results showed that omalizumab responders had significantly younger age in the adult subgroup, higher pretreatment total serum IgE level, percent predicted FEV1 and FeNO than that non-responder. We further confirmed that higher blood eosinophil counts and total serum IgE levels are useful markers for selecting asthma patients who may benefit more from omalizumab.Pre-treatment blood eosinophil counts and total serum IgE level can be a useful efficacy predictor in selecting allergic asthma patients for omalizumab treatment.
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