静电纺丝
材料科学
膜
聚己内酯
生物相容性
伤口愈合
共价键
纳米复合材料
共价有机骨架
化学工程
纳米技术
多孔性
有机化学
化学
聚合物
复合材料
生物化学
工程类
冶金
生物
免疫学
作者
Yucheng Zou,Peng Wang,Aiping Zhang,Zeyu Qin,Li Yang,Yunlei Xianyu,Hui Zhang
标识
DOI:10.1021/acsami.1c19754
摘要
Covalent organic frameworks (COFs) possess fascinating features that have sparked increasing interest as drug carriers in biomedical applications. However, the promising properties of COFs in wound healing have rarely been reported. Herein, a facile one-pot method is reported to prepare a curcumin-loaded COF (CUR@COF) by the condensation reaction and the Schiff base reaction and to further incorporate CUR@COF into polycaprolactone (PCL) nanofibrous membranes (CUR@COF/PCL NFMs) through electrospinning to develop a pH-triggered drug release platform for wound dressing. CUR@COF has a high CUR loading capacity of 27.68%, and CUR@COF/PCL NFMs exhibit increased thermal stability, improved mechanical properties, good biocompatibility, and enhanced antibacterial and antioxidant activities. More importantly, CUR@COF-based membranes show a pH-responsive CUR release profile by protonation under acidic conditions, suggesting the promotion of CUR release from membranes under an acidic extracellular microenvironment. The histopathological analysis and immunofluorescence staining of an in vivo skin defect model indicate that CUR@COF/PCL NFMs can accelerate wound healing and skin regeneration by reducing the expression of inflammatory factors (TNF-α) and enhancing the expression of angiogenesis (VEGF). This work provides a new strategy by employing COF-based drug-encapsulated nanocomposites for wound dressing applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI