生物
计算生物学
基因
基因组
非编码RNA
遗传学
核糖核酸
编码
基因间区
长非编码RNA
小RNA
转录组
基因表达
作者
Tingting Li,Suya Wang,Rimao Wu,Xueya Zhou,Dahai Zhu,Yong Zhang
出处
期刊:Genomics
[Elsevier BV]
日期:2012-05-01
卷期号:99 (5): 292-298
被引量:139
标识
DOI:10.1016/j.ygeno.2012.02.003
摘要
Vertebrate genomes encode thousands of non-coding RNAs including short non-coding RNAs (such as microRNAs) and long non-coding RNAs (lncRNAs). Chicken (Gallus gallus) is an important model organism for developmental biology, and the recently assembled genome sequences for chicken will facilitate the understanding of the functional roles of non-coding RNA genes during development. The present study concerns the first systematic identification of lncRNAs using RNA-Seq to sample the transcriptome during chicken muscle development. A computational approach was used to identify 281 new intergenic lncRNAs in the chicken genome. Novel lncRNAs in general are less conserved than protein-coding genes and slightly more conserved than random non-coding sequences. The present study has provided an initial chicken lncRNA catalog and greatly increased the number of chicken ncRNAs in the non-protein coding RNA database. Furthermore, the computational pipeline presented in the current work will be useful for characterizing lncRNAs obtained from deep sequencing data.
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