Parathyroid hormone changes following denosumab treatment in postmenopausal osteoporosis

德诺苏马布 医学 特立帕肽 甲状旁腺激素 内科学 内分泌学 骨质疏松症 骨重建 维生素D与神经学 N-末端末端肽 双膦酸盐 养生 骨钙素 化学 碱性磷酸酶 生物化学
作者
Polyzois Makras,Stergios A. Pοlyzos,Αθανάσιος Παπαθεοδώρου,Panagiotis Kokkoris,Daniel Chatzifotiadis,Athanasios D. Anastasilakis
出处
期刊:Clinical Endocrinology [Wiley]
卷期号:79 (4): 499-503 被引量:59
标识
DOI:10.1111/cen.12188
摘要

Denosumab is a new potent antiresorptive treatment of osteoporosis that can potentially induce a compensatory increase in parathyroid hormone (PTH) levels. We aimed to evaluate the alteration of PTH 1 and 6 months after denosumab's administration with different regimens of calcium and vitamin D (Ca/D) supplementation.Prospective, multicenter, study in a relatively small, heterogeneous sample of postmenopausal women followed for 6 months.Forty seven postmenopausal women followed in 2 outpatient clinics, requiring onset or continuation of osteoporosis treatment. We administered 1 g calcium carbonate and 800 IU cholecalciferol daily for 6 months (Group A) or the double dose for the first month followed by the 1 g/800 IU Ca/D regimen for the next 5 months (Group B).Parathyroid hormone (PTH) alterations between and within groups, and their associations with serum Ca and bone markers.Parathyroid hormone (PTH) levels were significantly higher at month 1 and 6 only in Group A; Ca levels were significantly decreased at month 1 and returned to baseline values at month 6 within the same Group. The mean per cent change between month 1 and baseline for PTH [Δ(PTH1-0 )] was significantly higher in Group A than B (63·5% ± 28·2% vs -3·0% ± 4·7%, P = 0·029). Δ(PTH1-0 ) was correlated with the reciprocal Δ-changes of Ca (rs = -0·610; P = 0·002) and collagen type I C-terminal telopeptide (rs = -0·697; P = 0·003) only in Group A.An increase in PTH should be expected, at least following the first administration of denosumab in common clinical practice. The effect of this compensatory onsequence in bone metabolism warrants further investigation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
粉色完成签到,获得积分10
刚刚
C胖胖完成签到,获得积分10
1秒前
淡然冬灵发布了新的文献求助10
1秒前
如忆婧年完成签到,获得积分10
2秒前
Minguk发布了新的文献求助10
2秒前
2秒前
奋斗的剑发布了新的文献求助10
3秒前
3秒前
上官若男应助R_采纳,获得10
3秒前
美满花生发布了新的文献求助10
3秒前
穆空完成签到,获得积分10
4秒前
5秒前
敷斩完成签到,获得积分10
5秒前
6秒前
7秒前
7秒前
敷斩发布了新的文献求助10
8秒前
wang发布了新的文献求助10
9秒前
THEO完成签到 ,获得积分10
9秒前
9秒前
天天快乐应助牛小牛采纳,获得10
9秒前
科目三应助奥利安费采纳,获得10
10秒前
是真的发布了新的文献求助10
10秒前
CodeCraft应助JYM采纳,获得10
10秒前
11秒前
智慧吗喽发布了新的文献求助10
11秒前
额我认为发布了新的文献求助10
11秒前
乐观的中心完成签到,获得积分10
12秒前
12秒前
爆米花应助helly采纳,获得10
12秒前
华仔应助李小皮采纳,获得10
13秒前
上官若男应助墨影曦遇采纳,获得10
13秒前
八零完成签到,获得积分10
14秒前
霍师傅发布了新的文献求助40
14秒前
14秒前
青木发布了新的文献求助10
14秒前
14秒前
15秒前
可爱柠檬发布了新的文献求助10
16秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974426
求助须知:如何正确求助?哪些是违规求助? 3518788
关于积分的说明 11195842
捐赠科研通 3254946
什么是DOI,文献DOI怎么找? 1797649
邀请新用户注册赠送积分活动 877037
科研通“疑难数据库(出版商)”最低求助积分说明 806130