Role of precursor availability in control of monoamine biosynthesis in brain.

单胺类神经递质 生物合成 神经科学 化学 生物 生物化学 血清素 受体
作者
John D. Fernstrom
出处
期刊:Physiological Reviews [American Physiological Society]
卷期号:63 (2): 484-546 被引量:482
标识
DOI:10.1152/physrev.1983.63.2.484
摘要

Role of precursor availability in control of monoamine biosynthesis in brain.J D FernstromJ D FernstromPublished Online:01 Apr 1983https://doi.org/10.1152/physrev.1983.63.2.484MoreSectionsPDF (9 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByL-tryptophan administration and increase in cerebral serotonin levels: Systematic reviewEuropean Journal of Pharmacology, Vol. 836Why does the microbiome affect behaviour?24 April 2018 | Nature Reviews Microbiology, Vol. 16, No. 10Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: Lessons from genome-scale metabolic modelingMetabolic Engineering, Vol. 49Dietary dopamine depletion blunts reward network sensitivity to face trustworthiness5 April 2018 | Journal of Psychopharmacology, Vol. 32, No. 9Applications for α-lactalbumin in human nutrition29 March 2018 | Nutrition Reviews, Vol. 76, No. 6Effects of intravenous tryptophan infusion on thermoregulation in steers exposed to acute heat stress19 January 2018 | Animal Science Journal, Vol. 89, No. 5Determination of Tryptophan in Pharmaceutical Formulations Using a Sequential Injection–Zone Fluidic–Chemiluminescence Tubular Reactor14 December 2017 | Analytical Letters, Vol. 51, No. 6Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventionsAgeing Research Reviews, Vol. 42MicroRNA and Transcriptomic Profiling Showed miRNA-Dependent Impairment of Systemic Regulation and Synthesis of Biomolecules in Rag2 KO Mice27 February 2018 | Molecules, Vol. 23, No. 3IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesityProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 80Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging23 November 2017 | Nutrients, Vol. 9, No. 12Tryptophan overloading activates brain regions involved with cognition, mood and anxiety16 February 2017 | Anais da Academia Brasileira de Ciências, Vol. 89, No. 1A Perspective on the Safety of Supplemental Tryptophan Based on Its Metabolic Fates9 November 2016 | The Journal of Nutrition, Vol. 146, No. 12Stereoselective detection of amino acids with protein-modified single asymmetric nanoporesElectrochimica Acta, Vol. 215Branched-chain amino acids alter neurobehavioral function in ratsAnna Coppola, Brett R. 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Newgard15 February 2013 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 304, No. 4Effects and Side Effects Associated with the Non-Nutritional Use of Tryptophan by Humans17 October 2012 | The Journal of Nutrition, Vol. 142, No. 12Does acute tryptophan depletion affect peripheral serotonin metabolism in the intestine?1 February 2012 | The American Journal of Clinical Nutrition, Vol. 95, No. 3L -Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications23 March 2009 | International Journal of Tryptophan Research, Vol. 2Repeated Administration of Fresh Garlic Increases Memory Retention in RatsJournal of Medicinal Food, Vol. 11, No. 4Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the BrainThe Journal of Nutrition, Vol. 137, No. 6Tryptophan-deficient diet increases the neurochemical and behavioral response to amphetamineBrain Research, Vol. 1094, No. 1Exercise, Serum Free Tryptophan, and Central FatigueThe Journal of Nutrition, Vol. 136, No. 2Influence of supplemental magnesium, tryptophan, vitamin C, and vitamin E on stress responses of pigs to vibration1Journal of Animal Science, Vol. 83, No. 7Chronic increase of dietary l-tryptophan decreases gentle feather pecking behaviourApplied Animal Behaviour Science, Vol. 89, No. 1-2Na+-dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: mechanisms for neutral amino acid removalRobyn L. O'Kane, Juan R. Viña, Ian Simpson, andRichard A. Hawkins1 October 2004 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 287, No. 4Plasma precursors of brain catecholaminergic and serotonergic neurotransmitters in rehabilitation patients with ischemic stroke11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.Archives of Physical Medicine and Rehabilitation, Vol. 85, No. 5The source of cerebral insulinEuropean Journal of Pharmacology, Vol. 490, No. 1-3Association of tryptophan 2,3 dioxygenase gene polymorphism with autism1 January 2004 | American Journal of Medical Genetics, Vol. 125B, No. 1Reduced plasma levels of tyrosine, precursor of brain catecholamines, and of essential amino acids in patients with severe traumatic brain injury after rehabilitation11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors(s) or upon any organization with which the author(s) is/are associated.Archives of Physical Medicine and Rehabilitation, Vol. 84, No. 9Nutrition, brain function and cognitive performance☆Appetite, Vol. 40, No. 3Acute effect of simultaneous administration of tryptophan and ethanol on serotonin metabolites in the locus coeruleus in ratsEuropean Journal of Pharmacology, Vol. 462, No. 1-3Extracellular Hypothalamic Serotonin and Plasma Amino Acids in Response to Sequential Carbohydrate and Protein Meals5 September 2013 | Nutritional Neuroscience, Vol. 6, No. 2Effects of tryptophan depletion on central and peripheral chemoreflexes in manRespiratory Physiology & Neurobiology, Vol. 133, No. 3Regulatory pathways and uptake ofl-DOPA by capillary cerebral endothelial cells, astrocytes, and neuronal cellsB. Sampaio-Maia, M. P. Serrão, andP. Soares-da-Silva1 February 2001 | American Journal of Physiology-Cell Physiology, Vol. 280, No. 2Tryptophan-Free Diets: A Physiological Tool to Study Brain Serotonin FunctionF. Fadda1 October 2000 | Physiology, Vol. 15, No. 5Can nutrient supplements modify brain function?The American Journal of Clinical Nutrition, Vol. 71, No. 6Acute amino acids supplementation enhances pituitary responsiveness in athletesMedicine & Science in Sports & Exercise, Vol. 31, No. 12Activity of tryptophan hydroxylase and content of indolamines in discrete brain regions after a long-term hypoxic exposure in the ratBrain Research, Vol. 765, No. 1Effects of Environmental Lighting and Tryptophan Devoid Diet on the Rat Vaginal Cycle3 October 2008 | Archives of Physiology and Biochemistry, Vol. 105, No. 5Diurnal differences in L-tryptophan sleep and temperature effects in the ratBehavioural Brain Research, Vol. 65, No. 2Acute tryptophan depletion aggravates premenstrual syndromeJournal of Affective Disorders, Vol. 32, No. 1Effects of carbohydrate and protein meals on cardiovascular levels and reactivityBiological Psychology, Vol. 38, No. 1Aspartame consumption: lack of effects on neural functionThe Journal of Nutritional Biochemistry, Vol. 5, No. 6Acute tryptophan depletion in bulimia: Effects on large neutral amino acidsBiological Psychiatry, Vol. 35, No. 6Effects of histamine on 5-hydroxytryptaminergic neuronal activity in the rat hypothalamusEuropean Journal of Pharmacology, Vol. 254, No. 1-2Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophreniaBiological Psychiatry, Vol. 35, No. 3Dietary amino acids and brain functionJournal of the American Dietetic Association, Vol. 94, No. 1Dopamine depletion in nigrostriatal neurons in the genetically diabetic ratBrain Research, Vol. 634, No. 1Altered cerebrospinal fluid amino acid pattern in the anorexia of aging: Relationship with biogenic amine metabolismLife Sciences, Vol. 53, No. 21Large changes in serum free tryptophan levels do not alter brain tryptophan levels: Studies in streptozotocin-diabetic ratsLife Sciences, Vol. 52, No. 11Regulation of serotonin synthesisProgress in Biophysics and Molecular Biology, Vol. 60, No. 1Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and β2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patientsJournal of Neuroimmunology, Vol. 40, No. 1Administration of tryptophan-enriched diets to pregnant rats retards the development of the serotonergic system in their offspringDevelopmental Brain Research, Vol. 68, No. 2β-Adrenergic regulation of amine precursor amino acid transport across the blood-brain barrierEuropean Journal of Pharmacology, Vol. 215, No. 2-3Platelet serotonin and plasma tryptophan decreases in endogenous depression. Clinical, therapeutic, and biological correlationsJournal of Affective Disorders, Vol. 24, No. 2Relationship between serotonergic measures in periphery and the brain of mouseLife Sciences, Vol. 51, No. 1Postoperative pain treated by intravenous l-tryptophan: a double-blind study versus placebo in cholecystectomized patientsPain, Vol. 47, No. 2l-Tryptophan supplementation does not affect postoperative pain intensity or consumption of analgesicsPain, Vol. 44, No. 3An appraisal of chemical aversion (emetic therapy) approaches to alcoholism treatmentBehaviour Research and Therapy, Vol. 29, No. 5Inhibition of phosphoenolpyruvate carboxykinase activity appears to be the key biochemical lesion in the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in ratsChemosphere, Vol. 23, No. 11-12The influence of dietary protein and amino acids on brain functionTrends in Food Science & Technology, Vol. 2Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived ratsBrain Research Bulletin, Vol. 25, No. 6Decreased plasma tryptophan concentration in major depression: relationship to melancholia and weight lossJournal of Affective Disorders, Vol. 20, No. 3Effects of l-tryptophan and other amino acids on electroencephalographic sleep in the ratBrain Research, Vol. 528, No. 2Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the dietThe Journal of Nutritional Biochemistry, Vol. 1, No. 10Role of central serotonergic systems in the development of hypertension in spontaneously hypertensive ratsBrain Research, Vol. 516, No. 1Injected tryptophan increases brain but not plasma tryptophan levels more in ethanol treated ratsLife Sciences, Vol. 47, No. 11Blunted ACTH and cortisol response to afternoon tryptophan infusion in euthymic bipolar patientsPsychiatry Research, Vol. 31, No. 1Clinical studies of 5-HT function using I.V. l-TryptophanProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 14, No. 4Medial hypothalamic serotonin: role in circadian patterns of feeding and macronutrient selectionBrain Research, Vol. 503, No. 1TREATMENT OF NARCOLEPSY WITH L-TYROSINE: DOUBLE-BLIND PLACEBO-CONTROLLED TRIALThe Lancet, Vol. 334, No. 8671In vivo tyrosine hydroxylation rate in retina: effects of phenylalanine and tyrosine administration in rats pretreated with p-chlorophenylalanineBrain Research, Vol. 499, No. 2Systemic endotoxin increasesl-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortexBrain Research, Vol. 491, No. 1Aspartame fails to facilitate pentylenetetrazol-induced convulsions in CD-1 miceToxicology and Applied Pharmacology, Vol. 98, No. 3Diurnal rhythm in absolute and relative concentrations of large neutral amino acids in human plasmaJournal of Psychiatric Research, Vol. 23, No. 3-4Diurnal rhythms in rat plasma amino acidsLife Sciences, Vol. 45, No. 11Decreased plasma tryptophan levels in major depressionJournal of Affective Disorders, Vol. 16, No. 1The psychoneuroendocrinology of diabetes mellitus in rodentsPsychoneuroendocrinology, Vol. 14, No. 4Effects of cocaine on release and uptake of dopamine in vivo: Differentiation by mathematical modelingPharmacology Biochemistry and Behavior, Vol. 31, No. 2Neuroanatomical regions of the chick brain involved in monitoring amino acid deficient dietsBrain Research Bulletin, Vol. 21, No. 4Assessment of [ 11 C]-L-Methionine Transport into the Human Brain29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 8, No. 3Effects of branched-chain amino acids on postprandial 3-OH butyrate and glucagon in the baboonMetabolism, Vol. 37, No. 5A twin study of amino acid concentrations in cerebrospinal fluidJournal of Psychiatric Research, Vol. 22, No. 1β-adrenergic control of brain uptake of large neutral amino acidsLife Sciences, Vol. 42, No. 17Modeling the dopaminergic nerve terminalJournal of Neuroscience Methods, Vol. 22, No. 3Effect of decarboxylase inhibitors on brain p-tyrosine levelsBiochemical Pharmacology, Vol. 36, No. 8Diabetes-induced changes in monoamine concentrations of rat hypothalamic nucleiBrain Research, Vol. 409, No. 2Complex temporal changes in 5-hydroxytryptamine synthesis in the central nervous system induced by experimental polyarthritis in the ratPain, Vol. 28, No. 2Protein consumption increases tyrosine concentration and in vivo tyrosine hydroxylation rate in the light-adapted rat retinaBrain Research, Vol. 401, No. 2Effect of tyrosine administration of dopa accumulation in light- and dark-adapted retinas from normal and diabetic ratsLife Sciences, Vol. 39, No. 22Sympathetic control of tryptophan uptake and morphine analgesia in stressed ratsEuropean Journal of Pharmacology, Vol. 126, No. 1-2Increased dietary leucine changes the rhythm of prolactin secretionMetabolism, Vol. 35, No. 7New studies on the cerebrovascular endothelium — possible relevance to the interpretation of ‘precursor-loading’ experimentsTrends in Pharmacological Sciences, Vol. 7Catecholaminergic-serotonergic balance in the CNS and reproductive cycling in aging ratsNeurobiology of Aging, Vol. 7, No. 1Plasma tryptophan and anorexia in human cancerEuropean Journal of Cancer and Clinical Oncology, Vol. 22, No. 1The synthesis and metabolism of catecholamines in the spinal cord of the rat after acute and chronic transectionsBrain Research, Vol. 347, No. 1Plasma tyrosine/neutral amino acid ratio correlated with clinical response to nortriptyline in endogenously depressed patientsJournal of Affective Disorders, Vol. 9, No. 3Effects of branched-chain amino acids on β-endorphin in the pituitary of the ratNeuroscience Letters, Vol. 58, No. 3Altered precursor availability and metabolism of monoamines in the brain caused by the injection of physiologic saline to suckling rats: On the reliability of saline “controls” in neurochemical studiesNeurochemistry International, Vol. 7, No. 4In vivo tyrosine hydroxylation in the diabetic rat retina: Effect of tyrosine administrationBrain Research, Vol. 298, No. 1Antihypertensive effects of l-tryptophan are not mediated by brain serotoninBrain Research, Vol. 295, No. 2 More from this issue > Volume 63Issue 2April 1983Pages 484-546 Copyright & PermissionsCopyright © 1983 by American Physiological Societyhttps://doi.org/10.1152/physrev.1983.63.2.484PubMed6132421History Published online 1 April 1983 Published in print 1 April 1983 Metrics

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