Source of kidney determines blood pressure in young renal transplanted rats

血压 医学 移植 肾切除术 高血压前期 肾功能 内科学 双侧肾切除术 内分泌学 肾移植 肾血流 泌尿科
作者
Daniel Kopf,R. Waldherr,Rainer Rettig
出处
期刊:American Journal of Physiology-renal Physiology [American Physiological Society]
卷期号:265 (1): F104-F111 被引量:47
标识
DOI:10.1152/ajprenal.1993.265.1.f104
摘要

Recipients of a renal graft from adult stroke-prone spontaneously hypertensive rat (SHRSP) but not normotensive Wistar-Kyoto rat (WKY) donors have been shown to develop posttransplantation hypertension. To investigate whether hypertension would also travel with the kidneys from young prehypertensive SHRSP and whether the age-related increase in blood pressure in F1 hybrids (F1H) bred from SHRSP and WKY parents was attenuated by early bilateral nephrectomy and transplantation of a WKY kidney, we transplanted kidneys from 14 male SHRSP and 16 WKY donors aged 35-42 days to young male F1H. Recipients had both native kidneys removed. Fifteen unilaterally nephrectomized nontransplanted F1H served as controls. At the time when kidneys were harvested for transplantation, systolic blood pressures in young SHRSP and WKY donors were not significantly different (114 +/- 5 vs. 113 +/- 3 mmHg). After transplantation, recipients of an SHRSP kidney rapidly developed posttransplantation hypertension with systolic blood pressures above 180 mmHg at 3 mo after transplantation. In contrast, systolic blood pressure in recipients of a WKY kidney rose only slightly with increasing age and remained significantly lower than in non-transplanted controls. Transplanted rats exhibited normal weight gain, and renal function (glomerular filtration rate, renal blood flow) in grafted kidneys was well preserved; plasma renin activity was reduced compared with nontransplanted controls. These data demonstrate that 1) hypertension can be transmitted to normotensive recipients by transplantation of a kidney from young prehypertensive SHRSP donors and 2) the age-related increase in arterial pressure in F1H is attenuated by early bilateral nephrectomy and transplantation of a WKY kidney.(ABSTRACT TRUNCATED AT 250 WORDS)
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
IMALL完成签到,获得积分10
1秒前
西早07完成签到,获得积分10
2秒前
隐形曼青应助KK采纳,获得10
2秒前
小燚完成签到 ,获得积分10
3秒前
柠檬完成签到 ,获得积分10
3秒前
flash完成签到,获得积分10
3秒前
星辰大海应助YZZ采纳,获得10
3秒前
昏睡的眼神完成签到 ,获得积分10
4秒前
自然怀梦完成签到,获得积分10
5秒前
cdercder应助碧蓝问梅采纳,获得30
5秒前
qqqyy完成签到,获得积分10
5秒前
勤劳弘文完成签到,获得积分10
5秒前
研友_VZG7GZ应助唐帅采纳,获得10
5秒前
泪雨煊发布了新的文献求助10
5秒前
可耐的紫夏完成签到,获得积分10
6秒前
航航完成签到,获得积分10
6秒前
LinYX发布了新的文献求助10
7秒前
方圆几里完成签到,获得积分10
7秒前
万能图书馆应助hwiseo采纳,获得30
7秒前
喜悦幻雪完成签到,获得积分10
7秒前
闪闪青雪完成签到,获得积分10
7秒前
杂化轨道退役研究员完成签到,获得积分10
7秒前
吕小布完成签到,获得积分10
7秒前
8秒前
Yiling完成签到,获得积分10
8秒前
朴素的问枫完成签到,获得积分10
8秒前
Zfx完成签到,获得积分10
9秒前
zhangshumin完成签到,获得积分10
9秒前
久念发布了新的文献求助10
9秒前
10秒前
欢喜怀绿完成签到,获得积分10
10秒前
欢呼阁完成签到,获得积分10
10秒前
冷傲鸡翅完成签到,获得积分10
10秒前
11秒前
早睡早起发布了新的文献求助10
11秒前
free完成签到,获得积分10
11秒前
11秒前
泪雨煊完成签到,获得积分20
12秒前
刘奶奶的牛奶完成签到,获得积分10
12秒前
无语的采柳完成签到 ,获得积分10
12秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2500
Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation 2000
Applications of Emerging Nanomaterials and Nanotechnology 1111
Agaricales of New Zealand 1: Pluteaceae - Entolomataceae 1040
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Neuromuscular and Electrodiagnostic Medicine Board Review 700
지식생태학: 생태학, 죽은 지식을 깨우다 600
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3466947
求助须知:如何正确求助?哪些是违规求助? 3059758
关于积分的说明 9067868
捐赠科研通 2750230
什么是DOI,文献DOI怎么找? 1509108
科研通“疑难数据库(出版商)”最低求助积分说明 697126
邀请新用户注册赠送积分活动 696953