Visceral Obesity and Risk of High Grade Disease in Clinical T1a Renal Cell Carcinoma

No AccessJournal of UrologyAdult Urology1 Feb 2013Visceral Obesity and Risk of High Grade Disease in Clinical T1a Renal Cell Carcinoma Yao Zhu, Hong-Kai Wang, Hai-Liang Zhang, Xu-Dong Yao, Shi-Lin Zhang, Bo Dai, Yi-Jun Shen, Xiao-Hang Liu, Liang-Ping Zhou, and Ding-Wei Ye Yao ZhuYao Zhu Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China , Hong-Kai WangHong-Kai Wang Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China , Hai-Liang ZhangHai-Liang Zhang Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China , Xu-Dong YaoXu-Dong Yao Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China , Shi-Lin ZhangShi-Lin Zhang Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China , Bo DaiBo Dai Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China , Yi-Jun ShenYi-Jun Shen Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China , Xiao-Hang LiuXiao-Hang Liu Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China , Liang-Ping ZhouLiang-Ping Zhou Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China , and Ding-Wei YeDing-Wei Ye Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China View All Author Informationhttps://doi.org/10.1016/j.juro.2012.09.030AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Accurate assessment of disease characteristics is a prerequisite for treatment decision making regarding small renal masses. In this study we evaluate the association between visceral obesity and Fuhrman grade in patients with cT1a renal cell carcinoma. Materials and Methods: We retrospectively collected data on 186 patients with surgically treated cT1a renal cell carcinoma. Single slice computerized tomography was used to measure the area of visceral and subcutaneous adipose tissue. Visceral obesity was calculated as the proportion of visceral adipose tissue to overall adipose tissue. Other analyzed factors included clinical characteristics (age, gender, body mass index and tumor size) and anatomical features of the tumor defined by the R.E.N.A.L. nephrometry score. The association between predictors and high grade disease (Fuhrman grade III or IV) were assessed using logistic regression analyses. Results: A total of 47 (25.3%) tumors were classified as high grade. The percentage of visceral adipose tissue was higher in male participants but did not correlate with body mass index, age or tumor size. In univariate analyses the percentage of visceral adipose tissue and tumor size were significantly associated with higher Fuhrman grade. Multivariate analysis showed that the percentage of visceral adipose tissue (OR 1.06, p = 0.0018) and tumor size (OR 1.91, p = 0.047) were independent predictors of high grade cancer. Addition of the percentage of visceral adipose tissue to a model including clinical characteristics and anatomical features of the tumor remarkably improved its discriminatory ability (p = 0.0010). Conclusions: Increased visceral obesity was found to be strongly associated with higher Fuhrman grade in patients with cT1a renal cell carcinoma. Further studies are needed to confirm these findings and discover the underlying biological mechanism. References 1 : Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer2010; 127: 2893. 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Google Scholar © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byLaguna M (2020) Re: Effect of Obesity and Overweight Status on Complications and Survival after Minimally Invasive Kidney Surgery in Patients with Clinical T2-4 Renal MassesJournal of Urology, VOL. 204, NO. 2, (383-384), Online publication date: 1-Aug-2020.Park Y, Lee J, Kim K, Kook H, Lee H, Kim K, Lee S, Byun S and Lee S (2014) Visceral Obesity in Predicting Oncologic Outcomes of Localized Renal Cell CarcinomaJournal of Urology, VOL. 192, NO. 4, (1043-1049), Online publication date: 1-Oct-2014.Steers W (2012) This Month in Adult UrologyJournal of Urology, VOL. 189, NO. 2, (405-406), Online publication date: 1-Feb-2013.Laguna M (2013) Re: Practice-Setting and Surgeon Characteristics Heavily Influence the Decision to Perform Partial Nephrectomy among American Urologic Association SurgeonsJournal of Urology, VOL. 190, NO. 3, (864-864), Online publication date: 1-Sep-2013. Volume 189Issue 2February 2013Page: 447-453 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.Keywordsmultivariate analysisobesityabdominalx-ray computedrenal cellcarcinomatomographyprognosisMetricsAuthor Information Yao Zhu Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China Equal study contribution. More articles by this author Hong-Kai Wang Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China Equal study contribution. More articles by this author Hai-Liang Zhang Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China More articles by this author Xu-Dong Yao Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China More articles by this author Shi-Lin Zhang Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China More articles by this author Bo Dai Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China More articles by this author Yi-Jun Shen Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China More articles by this author Xiao-Hang Liu Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China More articles by this author Liang-Ping Zhou Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Fudan University Shanghai Medical College, Shanghai, China More articles by this author Ding-Wei Ye Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China More articles by this author Expand All Advertisement PDF downloadLoading ...