西地那非
医学
高海拔对人类的影响
安慰剂
肺动脉高压
缺氧(环境)
高度(三角形)
肺动脉
心脏病学
内科学
麻醉
血流动力学
缺氧性肺血管收缩
氧气
化学
替代医学
几何学
数学
有机化学
病理
解剖
标识
DOI:10.1517/14656566.6.5.835
摘要
AbstractExposure to high altitude causes alveolar hypoxia and induces pulmonary hypertension (PH) with consequent limitation of exercise capacity. To assess the impact of sildenafil on haemodynamic and clinical parameters, and on aerobic performance, 12 young healthy unacclimatised subjects were studied (6 received sildenafil 40 mg t.i.d. and 6 received placebo) at sea level and high altitude. Systolic pulmonary artery pressure increased at high altitude, but normalised with sildenafil. The altitude-induced decrease in maximal O2 consumption was significantly smaller with sildenafil than with placebo. Enhancing pulmonary circulation with sildenafil safely protects against the high altitude-induced PH and improves gas exchange.Keywords:: altitude-induced hypoxaemiacardiac outputexercisepulmonary hypertensionsildenafil
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