微生物群
疾病
生物
肠道菌群
肠道微生物群
免疫系统
发病机制
医学
失调
生物信息学
免疫学
病理
作者
Pengqing Nie,Zhiqiang Li,Yimeng Wang,Yubing Zhang,Mengna Zhao,Jie Luo,Shiming Du,Zixin Deng,Jincao Chen,Yunfu Wang,Shi Chen,Lianrong Wang
摘要
Abstract Ongoing studies have determined that the gut microbiota is a major factor influencing both health and disease. Host genetic factors and environmental factors contribute to differences in gut microbiota composition and function. Intestinal dysbiosis is a cause or a contributory cause for diseases in multiple body systems, ranging from the digestive system to the immune, cardiovascular, respiratory, and even nervous system. Investigation of pathogenesis has identified specific species or strains, bacterial genes, and metabolites that play roles in certain diseases and represent potential drug targets. As research progresses, gut microbiome–based diagnosis and therapy are proposed and applied, which might lead to considerable progress in precision medicine. We further discuss the limitations of current studies and potential solutions.
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