咪唑安定
镇静
医学
麻醉
机械通风
重症监护室
丸(消化)
脑电双频指数
镇静剂
止痛药
装载剂量
重症监护
外科
重症监护医学
作者
Dilek Altun,Gülay Eren,Halil Çetingök,Gülsüm Oya Hergünsel,Zafer Çukurova
出处
期刊:Ağrı
[Kare Publishing]
日期:2019-01-01
被引量:2
标识
DOI:10.14744/agri.2019.59244
摘要
The aim of this prospective, randomized study was to investigate the effect of magnesium added to midazolam on the hemodynamics, transition time to a T-piece, mechanical ventilation duration, additional sedative-analgesic requirement using bispectral index (BIS) monitorization and sedation scales.Fifty critically ill patients receiving mechanical ventilation support in the intensive care unit were randomly assigned to 2 groups. Group I received a 0.03-0.3 mg/kg bolus loading dose+0.03-02 mg/kg/hour midazolam infusion; Group II received a 2 g bolus at 30 minutes, 16 mg/24-hour magnesium infusion+0.03-02 mg/kg/hour midazolam infusion. BIS levels and sedation levels were continuously monitored.The duration of mechanical ventilation in Group I was longer than that of Group II (31+-12 hours, 19+-11 hours, respectively; p<0.01). The length of time to start spontaneous breathing trials with a T-piece was greater in Group I than in Group II (27+-11 hours, 16+-11 hours, respectively; p<0.01). The 48-hour insulin requirement of Group I was greater than that of Group II (p<0.05).Adding intravenous magnesium to the traditional sedation protocols in the intensive care unit decreased midazolam use as well as the additional analgesic requirement and mechanical ventilatory support duration without any side effects.
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