Mussel-Inspired Cell/Tissue-Adhesive, Hemostatic Hydrogels for Tissue Engineering Applications

自愈水凝胶 胶粘剂 组织工程 肿胀 的 生物医学工程 细胞粘附 多孔性 明胶 化学工程 伤口愈合 化学 材料科学 纤维蛋白 高分子化学 生物相容性 再生(生物学) 脚手架
作者
Maduru Suneetha,Kummara Madhusudana Rao,Sung Soo Han
出处
期刊:ACS omega [American Chemical Society]
卷期号:4 (7): 12647-12656 被引量:35
标识
DOI:10.1021/acsomega.9b01302
摘要

The combination of multiple physiological (swelling, porosity, mechanical, and biodegradation) and biological (cell/tissue-adhesive, cell proliferation, and hemostatic) properties on a single hydrogel has great potential for skin tissue engineering. Adhesive hydrogels based on polydopamine (PDA) have become the most popular in the biomedical field; however, integrating multiple properties on a single adhesive hydrogel remains a challenge. Here, inspired by the chemistry of mussels, we developed PDA-sodium alginate-polyacrylamide (PDA-SA-PAM)-based hydrogels with multiple physiological and biological properties for skin tissue engineering applications. The hydrogels were prepared by alkali-induced polymerization of DA followed by complexation with SA in PAM networks. The chemical composition of the hydrogels was characterized by X-ray photoelectron spectroscopy. PDA-SA complexed chains were homogeneously dispersed in the PAM network and exhibited good elasticity and excellent mechanical properties, such as a compressive stress of 0.24 MPa at a compression strain of 70% for 0.4PDA-SA-PAM. The adhesive hydrogel also maintained a highly interconnected porous structure (∼94% porosity) along with PDA microfibrils. The hydrogel possesses outstanding swelling and biodegradability properties. Owing to the presence of the PDA-SA complex in the PAM network, the hydrogels show good adhesion to various substrates (plastic, skin, glass, computer screens, and leaves); for example, the adhesive strength of the 0.4PDA-SA-PAM to porcine skin was 24.5 kPa. The adhesive component of the PDA-SA chains in the PAM network significantly improves the cell proliferation, cell attachment, cell spreading, and functional expression of human skin fibroblasts (CCD-986sk) and keratinocytes. Moreover, the PDA chains exhibited good hemostatic properties, resulting in rapid blood coagulation. Considering their excellent cell affinity, and rapid blood coagulation ability, these mussel-inspired hydrogels have substantial potential for skin tissue engineering applications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助科研通管家采纳,获得10
刚刚
无花果应助科研通管家采纳,获得10
刚刚
搜集达人应助科研通管家采纳,获得10
刚刚
香蕉觅云应助科研通管家采纳,获得10
刚刚
烟花应助科研通管家采纳,获得10
刚刚
科研通AI2S应助科研通管家采纳,获得10
1秒前
1秒前
Hello应助科研通管家采纳,获得10
1秒前
xiaoGuo应助科研通管家采纳,获得10
1秒前
彭于晏应助科研通管家采纳,获得10
1秒前
ding应助科研通管家采纳,获得10
1秒前
JamesPei应助科研通管家采纳,获得10
1秒前
小马甲应助科研通管家采纳,获得10
1秒前
1秒前
1秒前
Mr发布了新的文献求助10
1秒前
lysixsixsix完成签到,获得积分10
2秒前
婳祎完成签到 ,获得积分10
2秒前
尊敬的yy完成签到,获得积分10
2秒前
tuotuo发布了新的文献求助10
3秒前
hh完成签到,获得积分10
3秒前
4秒前
醉熏的荣轩完成签到,获得积分20
5秒前
Anqi完成签到 ,获得积分10
5秒前
6秒前
cd发布了新的文献求助10
6秒前
7秒前
7秒前
8秒前
8秒前
10秒前
张熙媛发布了新的文献求助10
11秒前
Lucas应助贺飞风采纳,获得10
12秒前
李振华发布了新的文献求助10
12秒前
leadsyew发布了新的文献求助10
12秒前
Jasper应助wind采纳,获得10
13秒前
上官若男应助HP采纳,获得10
13秒前
14秒前
大锤发布了新的文献求助10
18秒前
18秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Chen Hansheng: China’s Last Romantic Revolutionary 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3141127
求助须知:如何正确求助?哪些是违规求助? 2792031
关于积分的说明 7801479
捐赠科研通 2448267
什么是DOI,文献DOI怎么找? 1302482
科研通“疑难数据库(出版商)”最低求助积分说明 626591
版权声明 601226