医学
利钠肽
多发性骨髓瘤
激素原
内科学
透析
肾功能
胃肠病学
心脏病学
泌尿科
心力衰竭
激素
作者
С. В. Семочкин,E. N. Misyurina,Е. И. Желнова,E. V. Yurova,Д. Э. Гаглоева,Н. А. Арефьева,А. И. Ушакова,O.N. Kotenko Kotenko,Tatiana Tolstykh,D.O. Sinyavkin,Е. А. Baryakh,K. V. Yatskov,И. В. Самсонова,М. А. Лысенко
标识
DOI:10.1007/s10517-019-04506-z
摘要
Prognostic value of N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP) was analyzed in patients with multiple myeloma complicated by dialysisdependent renal failure. The prospective study included 20 patients with newly diagnosed multiple myeloma. The concentrations of NT-proBNP were measured before antimyeloma chemotherapy. The median age of the patients was 67 (63-76) years. The median glomerular filtration rate was 4 (4, 5) ml/min/1.73 m2. For overall survival, the area under ROC curve was 0.75 and the cut-off point was 7000 pg/ml. At median follow-up of 17.3 months, the overall survival was 76.6±14.8 and 27.3±13.4% (p=0.02) for cases with NT-proBNP levels below and above the cut-off point, respectively. There were no cases of death due to cardiovascular causes. We concluded that the increase in serum concentration of NT-proBNP>7400 pg/ml is associated with the severity of kidney damage and the risk of non-cardiac mortality.
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