MHC I级
抗原处理
与抗原处理相关的转运体
川东北74
生物
主要组织相容性复合体
MHC II级
转录因子
MHC限制
抗原呈递
抄写(语言学)
细胞生物学
计算生物学
免疫系统
遗传学
T细胞
基因
哲学
语言学
作者
Marlieke L.M. Jongsma,Greta Guarda,Robbert M. Spaapen
标识
DOI:10.1016/j.molimm.2017.12.005
摘要
The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is hijacked in many pathological conditions. This affects MHC class I levels and peptide presentation at the cell surface leading to immune escape of cancer cells or microbes. It is therefore important to identify the molecular mechanisms behind MHC class I expression, processing and antigen presentation. The identification of NLRC5 as regulator of MHC class I transcription was a huge step forward in understanding the transcriptional mechanism involved. Nevertheless, many questions concerning MHC class I transcription are yet unsolved. Here we illuminate current knowledge on MHC class I and NLRC5 transcription, we highlight some remaining questions and discuss the use of quickly developing high-content screening tools to reveal unknowns in MHC class I transcription in the near future.
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