Carbohydrate antigen 125 and risk of heart failure readmissions in patients with heart failure and preserved ejection fraction

医学 心力衰竭 射血分数 四分位数 内科学 心脏病学 多元分析 置信区间
作者
Gema Miñana,Rafael de la Espriella,Patricia Palau,Pau Llàcer,Eduardo Núñez,Enrique Santas,Ernesto Valero,Miguel Lorenzo,Gonzalo Núñez,Vicent Bodı́,Raquel Heredia,Juan Sanchís,Antoni Bayés‐Genís,Francisco J. Chorro,Julio Núñez
出处
期刊:Scientific Reports [Nature Portfolio]
卷期号:12 (1) 被引量:10
标识
DOI:10.1038/s41598-022-05328-2
摘要

We aimed to assess the association between CA125 and the long-term risk of total acute heart failure (AHF) admissions in patients with an index hospitalization with AHF and preserved ejection fraction (HFpEF). We prospectively included 2369 patients between 2008 and 2019 in three centers. CA125 and NT-proBNP were measured during early hospitalization and evaluated as continuous and categorized in quartiles (Q). Negative binomial regressions were used to assess the association with the risk of recurrent AHF admission. The mean age of the sample patients was 76.7 ± 9.5 years and 1443 (60.9%) were women. Median values of CA125 and NT-proBNP were 38.3 (19.0-90.0) U/mL, and 2924 (1590-5447) pg/mL, respectively. During a median follow-up of 2.2 (0.8-4.6) years, 1200 (50.6%) patients died, and 2084 AHF admissions occurred in 1029 (43.4%) patients. After a multivariate adjustment, CA125, but not NT-proBNP, was positively and non-linearly associated with the risk of cumulative AHF-readmission (p < 0.001). Compared to Q1, patients belonging to Q2, Q3, and Q4 showed a stepwise risk increase (IRR = 1.29, 95% CI 1.08-1.55, p = 0.006; IRR = 1.35, 95% CI 1.12-1.63, p = 0.002; and IRR = 1.62, 95% CI 01.34-1.96, p < 0.001, respectively). In conclusion, CA125 predicted the risk of long-term AHF-readmission burden in patients with HFpEF and a recent admission for AHF.

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