已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Glucagon-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a double-blind, randomized, placebo-controlled study

Copeptin蛋白 内科学 内分泌学 尿崩症 医学 多饮 胰高血糖素 安慰剂 多尿 加压素 糖尿病 激素 病理 替代医学
作者
Cihan Atila,Odile Gaisl,Deborah R Vogt,Laura Werlen,Gabor Szinnai,Mirjam Christ-Crain
出处
期刊:European journal of endocrinology [Bioscientifica]
卷期号:187 (1): 65-74 被引量:10
标识
DOI:10.1530/eje-22-0033
摘要

The differential diagnosis of diabetes insipidus is challenging. The most reliable approaches are copeptin measurements after hypertonic saline infusion or arginine, which is a known growth hormone secretagogue but has recently also been shown to stimulate the neurohypophysis. Similar to arginine, glucagon stimulates growth hormone release, but its effect on the neurohypophysis is poorly studied.Double-blind, randomized, placebo-controlled trial including 22 healthy participants, 10 patients with central diabetes insipidus, and 10 patients with primary polydipsia at the University Hospital Basel, Switzerland.Each participant underwent the glucagon test (s.c. injection of 1 mg glucagon) and placebo test. The primary objective was to determine whether glucagon stimulates copeptin and to explore whether the copeptin response differentiates between diabetes insipidus and primary polydipsia. Copeptin levels were measured at baseline, 30, 60, 90, 120, 150, and 180 min after injection.In healthy participants, glucagon stimulated copeptin with a median increase of 7.56 (2.38; 28.03) pmol/L, while placebo had no effect (0.10 pmol/L (-0.70; 0.68); P < 0.001). In patients with diabetes insipidus, copeptin showed no relevant increase upon glucagon, with an increase of 0.55 (0.21; 1.65) pmol/L, whereas copeptin was stimulated in patients with primary polydipsia with an increase of 15.70 (5.99; 24.39) pmol/L. Using a copeptin cut-off level of 4.6pmol/L had a sensitivity of 100% (95% CI: 100-100) and a specificity of 90% (95% CI: 70-100) to discriminate between diabetes insipidus and primary polydipsia.Glucagon stimulates the neurohypophysis, and glucagon-stimulated copeptin has the potential for a safe, novel, and precise test in the differential diagnosis of diabetes insipidus.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
在水一方应助莫妮卡.宾采纳,获得10
1秒前
草拟大坝完成签到 ,获得积分0
2秒前
以乐完成签到 ,获得积分10
3秒前
大傻春完成签到 ,获得积分10
5秒前
搜集达人应助LUBBY采纳,获得10
7秒前
江城一霸完成签到,获得积分10
8秒前
墨水完成签到 ,获得积分10
10秒前
13秒前
豆豆应助zch采纳,获得30
13秒前
Jasper应助零慧采纳,获得10
14秒前
不与仙同完成签到 ,获得积分10
15秒前
15秒前
17秒前
CipherSage应助重要的乾采纳,获得10
18秒前
19秒前
19秒前
绾妤完成签到 ,获得积分10
21秒前
Owen应助哈比人linling采纳,获得10
22秒前
莫妮卡.宾发布了新的文献求助10
22秒前
LUBBY发布了新的文献求助10
23秒前
23秒前
king完成签到,获得积分10
24秒前
25秒前
25秒前
26秒前
冷冷完成签到 ,获得积分10
26秒前
Kevin完成签到,获得积分10
26秒前
denise完成签到 ,获得积分10
27秒前
Billy应助科研通管家采纳,获得10
27秒前
MRBBN应助科研通管家采纳,获得30
27秒前
爆米花应助科研通管家采纳,获得10
27秒前
无花果应助科研通管家采纳,获得10
27秒前
雨落瑾年完成签到,获得积分10
28秒前
29秒前
缘在山中应助大胆翎采纳,获得10
30秒前
liyifengli发布了新的文献求助10
30秒前
积极含羞草完成签到,获得积分10
30秒前
SCI发发完成签到,获得积分20
32秒前
34秒前
qqq完成签到 ,获得积分10
34秒前
高分求助中
Sustainability in ’Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
The ACS Guide to Scholarly Communication 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3072420
求助须知:如何正确求助?哪些是违规求助? 2726230
关于积分的说明 7493301
捐赠科研通 2373930
什么是DOI,文献DOI怎么找? 1258827
科研通“疑难数据库(出版商)”最低求助积分说明 610392
版权声明 596967