氢氧化物
材料科学
检出限
碳纳米管
电化学气体传感器
电化学
半胱氨酸
安培法
循环伏安法
化学工程
层状双氢氧化物
纳米技术
电极
无机化学
化学
有机化学
色谱法
物理化学
工程类
酶
作者
Ayesha Aziz,Muhammad Asif,Ghazala Ashraf,Tayyaba Iftikhar,Muhammad Ajmal,Hongfang Liu,Shenqi Wang
标识
DOI:10.1016/j.cej.2022.135985
摘要
L-cysteine is an imperative amino acid which exists in natural proteins and plays crucial roles in biological systems, thereby its sensitive and selective monitoring is extremely necessary. In this work, novel hybrid nanoarchitectures have been fabricated by wrapping positively charged NiAl layered double hydroxide (LDH) nanosheets on negatively charged carbon nanotubes (CNTs). The electrochemical behavior of [email protected] LDH hybrids having different concentrations of NiAl LDH precursor salts with fixed amount of CNTs have been explored in detection of L-cysteine using cyclic voltammetry and amperometry techniques. High conductivity of CNTs together with enhanced electrocatalytic properties of NiAl LDH and plentiful surface active sites are accountable to facilitate the direct detection of L-cysteine. Therefore, the fabricated electrode exhibits excellent sensing performance with 0.05 µM to 780 µM wide linear range, sensitivity of 351 μA mM−1 cm−2, low limit of detection upto 3 nM (S/N = 3), superb reproducibility and stability as well as brilliant selectivity against common interferents. Arising from remarkable efficiency, the [email protected] LDH based sensing system has been practically used in real-time detecting L-cysteine effluxes from different living cells upon stimulation as-well-as in-vitro monitoring of L-cysteine concentrations in human samples (urine and serum).
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