点击化学
共聚物
炔丙基
透明质酸
乙二醇
化学
高分子化学
流变学
高分子科学
组合化学
有机化学
聚合物
材料科学
催化作用
生物
复合材料
遗传学
作者
M. Saletti,Marco Paolino,Lavinia Ballerini,Germano Giuliani,Gemma Leone,Stefania Lamponi,M. Andreassi,Claudia Bonechi,Alessandro Donati,Daniele Piovani,Alberto Giacometti Schieroni,Agnese Magnani,Andrea Cappelli
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2022-05-11
卷期号:14 (5): 1041-1041
被引量:6
标识
DOI:10.3390/pharmaceutics14051041
摘要
An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight values were exploited in crosslinking by click-chemistry by using a hexa(ethylene glycol) spacer. The resulting HA-FA-HEG-CL materials showed an apparent lack of in vitro cytotoxic effects, tuneable water affinity, and rheological properties according to the crosslinking degree that suggests their applicability in different biomedical fields.
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