伤口愈合
体内
药理学
体外
再生(生物学)
成纤维细胞
细胞生物学
口服
化学
姜黄素
医学
生物化学
生物
免疫学
生物技术
作者
Faming Yang,Di Zhao,Kun Zhang,Zhouchi Wang,Yuxin Wang,Changcheng Wu,Shenghao Cui,Tingting Guo,Liqi Chen,Jingdi Chen
标识
DOI:10.1016/j.colsurfb.2022.112592
摘要
Oral administration of peptides/proteins with superior efficacy and fewer side effects is the most advantageous route of administration. In this study, we utilized controllable enzymatic (animal protease) hydrolysis technology to prepare active polypeptide self-assembling supramolecular (APs) from marine shellfish meat to explore the functional mechanism of APs in in vitro and in vivo (oral administration) experiments . In vitro experiments revealed that APs with self-assembly tendency had multifunctional activities. In vivo experiments indicated that oral administration of naturally safe APs could inhibited inflammation, promoted fibroblast proliferation and revascularization, and accelerated the epithelialization process, thus favoring a balanced repair tissue collagen I/III ratio and the promotion of hair follicle regeneration to achieve scarless healing, which was also relevant to "skin-gut" axis. These results showed that APs, as demonstrated in this study, promoted dermal wound healing in mice and may be developed and used to treat skin wounds.
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