医学
支气管肺发育不良
肺动脉高压
重症监护医学
疾病
血流动力学
病因学
心脏病学
内科学
儿科
怀孕
遗传学
生物
胎龄
作者
Philip T. Levy,Jonathan C. Levin,Kristen T. Leeman,Mary P. Mullen,Georg Hansmann,Stella Kourembanas
标识
DOI:10.1016/j.siny.2022.101351
摘要
Chronic pulmonary hypertension of infancy (cPHi) is a heterogeneous disease process that contributes to morbidity and mortality in preterm infants. cPHi is most commonly associated with chronic lung disease of prematurity and represents a unique phenotype of bronchopulmonary dysplasia. It is characterized by persistently elevated or newly rising pulmonary vascular resistance and pulmonary artery pressure beyond the first weeks of age. The high-pressure afterload on the right ventricle may or may not be tolerated, depending upon additional cardiovascular shunting and co-morbidities. A comprehensive clinical evaluation combined with advanced hemodynamic assessment by echocardiography and other cardiac imaging modalities help decipher the etiopathologies of disease, identify cardiopulmonary compromise earlier and guide individualized therapeutic intervention tailored by the phenotype. This review summarizes the underlying etiologies, risk factors for development, hemodynamic assessment, management, and follow-up of cPHi in preterm infants. We offer an algorithm for early detection of cPHi and outline research priorities.
科研通智能强力驱动
Strongly Powered by AbleSci AI