炎症
髓样
造血
免疫学
间质细胞
发病机制
骨髓
免疫系统
癌症研究
髓系细胞
医学
生物
作者
Ryan J. Stubbins,Uwe Platzbecker,Aly Karsan
出处
期刊:Blood
[American Society of Hematology]
日期:2022-04-25
卷期号:140 (10): 1067-1074
被引量:1
标识
DOI:10.1182/blood.2021015162
摘要
Abstract Chronic inflammation with aging (“inflammaging”) plays a prominent role in the pathogenesis of myeloid malignancies. Aberrant inflammatory activity affects many different cells in the marrow, including normal blood and stromal marrow elements and leukemic cells, in unique and distinct ways. Inflammation can promote selective clonal expansion through differential immune-mediated suppression of normal hematopoietic cells and malignant clones. We review these complex roles, how they can be understood by separating cell-intrinsic from extrinsic effects, and how this informs future clinical trials.
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