Hemocompatible Surfaces Through Surface-attached Hydrogel Coatings and their Functional Stability in a Medical Environment

涂层 材料科学 惰性 聚合物 高压灭菌器 粘附 基质(水族馆) 复合材料 纳米技术 化学工程 生物医学工程 化学 有机化学 地质学 工程类 海洋学 冶金 医学
作者
Julia Kim Meinzer,Michael Henze,C. K. Pandiyarajan,Oswald Prucker,Wolfgang Bothe,Friedhelm Beyersdorf,Jürgen Rühe
出处
期刊:Asaio Journal [Ovid Technologies (Wolters Kluwer)]
卷期号:Publish Ahead of Print 被引量:1
标识
DOI:10.1097/mat.0000000000001426
摘要

Blood compatible materials are a well-researched scientific field as such materials are required in a wide range of applications, for example, in heart-lung machines or ventricular assist devices. Surfaces coated with certain surface-bound neutral, water-swellable polymer networks have the ability to repel cells such as platelets and exhibit a significantly improved hemocompatibility. In this study, we investigate the interaction of platelets from whole blood with surfaces coated with photochemically generated surface-attached polymer networks based on polydimethyl acrylamide. As substrates medical-grade polyurethanes are used, and the networks are formed and attached to the substrate surfaces through C-H insertion reactions. The hydrogel-coated substrates are perfused with blood for extended periods of time. We show that the polymer coating prevents the adhesion of cells even at longer times of blood contact, regardless of the thickness of the coating employed. The surfaces can be sterilized following a standard autoclave procedure without any loss of function. Additionally, it is shown that the samples can be stored at least for 3 months under varying ambient conditions while retaining their functionality. The excellent blood compatibility, the possibility to coat even rather inert polymeric materials and the ability to handle the materials in an environment typical for a medical application make such coatings a promising candidate for future hemocompatible devices.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
millie发布了新的文献求助10
刚刚
刚刚
尊敬秋双发布了新的文献求助10
1秒前
Vesper完成签到,获得积分10
1秒前
wangyu发布了新的文献求助10
4秒前
tgd发布了新的文献求助10
5秒前
6秒前
7秒前
8秒前
8秒前
8秒前
9秒前
完美世界应助zhang0403采纳,获得10
9秒前
9秒前
zhaolee完成签到 ,获得积分10
10秒前
情怀应助LYH采纳,获得10
10秒前
10秒前
Ampace小老弟完成签到 ,获得积分10
11秒前
11秒前
朵朵完成签到,获得积分10
12秒前
狄鹤轩发布了新的文献求助10
12秒前
郑一发布了新的文献求助10
12秒前
大个应助小一采纳,获得10
13秒前
打打应助baekhyun采纳,获得10
13秒前
爆米花应助奶味蓝采纳,获得20
13秒前
12发布了新的文献求助10
13秒前
14秒前
14秒前
Tong发布了新的文献求助30
16秒前
16秒前
vivianfou完成签到,获得积分10
17秒前
燕小丙完成签到,获得积分10
17秒前
Vaibhav发布了新的文献求助10
18秒前
millie完成签到,获得积分20
20秒前
美满的书南完成签到,获得积分10
23秒前
23秒前
23秒前
24秒前
25秒前
虚幻井发布了新的文献求助10
26秒前
高分求助中
Continuum Thermodynamics and Material Modelling 4000
Production Logging: Theoretical and Interpretive Elements 2700
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
El viaje de una vida: Memorias de María Lecea 800
Luis Lacasa - Sobre esto y aquello 700
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3522937
求助须知:如何正确求助?哪些是违规求助? 3103910
关于积分的说明 9267916
捐赠科研通 2800665
什么是DOI,文献DOI怎么找? 1537075
邀请新用户注册赠送积分活动 715371
科研通“疑难数据库(出版商)”最低求助积分说明 708759