医学
胎儿
胎龄
周长
百分位
置信区间
内科学
怀孕
数学
几何学
生物
遗传学
统计
作者
Odessa P. Hamidi,Camille Driver,Jon G. Steller,Emma Peek,Lorenzo Monasta,Christoph Lees,Diane L. Gumina,Greggory R. DeVore,John C. Hobbins,Henry L. Galan
摘要
Objectives Umbilical vein flow (UVF) is reduced in fetal growth restriction (FGR). We compared absolute and size-adjusted UVF (estimated fetal weight [EFW] and abdominal circumference [AC]) and rates of abnormal UVF parameters (<10th percentile) among FGR fetuses meeting Delphi criteria (FGR-D) against small for gestational age (SGA) fetuses and appropriate for gestational age (AGA) controls. Methods Absolute UVF, UVF/EFW, and UVF/AC were compared between 73 FGR pregnancies (35 FGR-D, 38 SGA) and 108 AGA controls. Rates of abnormal UVF were compared to abnormal umbilical artery pulsatility index (UAPI). Independent samples t-tests, Mann–Whitney U, odds ratio (OR), chi-squared, and Fisher's exact tests were used as appropriate. Results Mean absolute UVF was significantly decreased in FGR-D compared to AGA (P = .0147), but not between SGA and AGA fetuses. The incidence of both abnormal absolute UVF and UVF/AC values (<10th centile) was higher among late-onset FGR fetuses versus AGA fetuses (UVF: OR 2.7, confidence interval [CI] 1.37–5.4; UVF/AC: OR 2.73, CI 1.37–5.4). UVF was more frequently abnormal than UAPI and in only two fetuses were both Doppler values abnormal. Conclusion Absolute UVF is altered in late-onset FGR, and most pronounced among FGR-D. UVF may provide additional insight into fetal compromise in those affected by growth restriction.
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