光学相干层析成像
共焦
临床前影像学
离体
拉曼光谱
生物医学工程
共焦显微镜
光学
体内
镜头(地质)
材料科学
计算机科学
医学
生物
物理
生物技术
作者
Xiaojing Ren,Kan Lin,Chao-Mao Hsieh,Linbo Liu,Xin Ge,Quan Liu
摘要
We report a joint system with both confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) modules capable of quickly addressing the region of interest in a tissue for targeted Raman measurements from OCT. By using an electrically tunable lens in the Raman module, the focus of the module can be adjusted to address any specific depth indicated in an OCT image in a few milliseconds. We demonstrate the performance of the joint system in the depth dependent measurements of an ex vivo swine tissue and in vivo human skin. This system can be useful in measuring samples embedded with small targets, for example, to identify tumors in skin in vivo and assessment of tumor margins, in which OCT can be used to perform initial real-time screening with high throughput based on morphological features to identify suspicious targets then CRS is guided to address the targets in real time and fully characterize their biochemical fingerprints for confirmation.
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