A combination of immunohistochemical markers, MUC1, MUC5AC, PAX8 and growth pattern for characterization of mucinous neoplasm of the ovary

医学 粘液癌 旅客8 黏液性囊腺瘤 病理 粘液性囊腺癌 卵巢 免疫组织化学 卵巢癌 组织学 粘液瘤 癌症 生物标志物 腺癌 内科学 生物 基因 转录因子 胰腺 生物化学
作者
Anca Chelariu-Raicu,Eva Holley,Doris Mayr,Frederick Klauschen,Fabienne S. Wehweck,Miriam Rottmann,Mirjana Kessler,Till Kaltofen,Bastian Czogalla,Fabian Trillsch,Sven Mahner,Elisa Schmoeckel
出处
期刊:International Journal of Gynecological Cancer [BMJ]
卷期号:32 (5): 662-668 被引量:5
标识
DOI:10.1136/ijgc-2021-003104
摘要

Because mucinous carcinomas are rare tumors that affect several organ sites and are known to originate from different tissues, leading to frequent misdiagnoses, the objective was to characterize the differences between primary mucinous tumors of the ovary and metastatic mucinous cancer to the ovary by studying the expression pattern of several candidate biomarkers.Tissue samples of mucinous histology were obtained between 1985 and 2015. Individual ovary and colon tissue samples were analyzed, including standard (PAX8, CK20, CK7, CDX2, SATB2, estrogen/progesterone) and new (MUC1, MUC5AC) biomarkers, which were then scored for immunoreactivity semi-quantitatively.The study cohort included 98 mucinous tumor samples, including benign mucinous cystadenoma (n=24), mucinous borderline tumors (n=24), mucinous carcinomas (n=40), and metastatic mucinous ovarian carcinomas (n=10). A strong positive correlation was found between PAX8 scoring (p=0.003), CK7 scoring (p=0.0001), and MUC1 scoring (p=0.001) in primary mucinous ovarian cancer. Tumors of increasing invasiveness were analyzed and a significant decrease in the scoring of MUC5AC (p=0.001) was observed, with a stronger expression in adenomas (87%) and borderline tumors (75%), and a lower expression in mucinous cancers (42%). Patients survived significantly longer when their tumors expressed high PAX8 and showed an expansile invasion pattern (p=0.005 and p=0.015, respectively) compared with patients with PAX8-negative tumors and destructive invasion pattern.The study data support the diagnostic value of MUC1 as a new biomarker to differentiate between primary and metastatic mucinous ovarian cancer. In addition, the tumor growth pattern along with the PAX8 immunophenotype might represent potential prognostic biomarkers for primary mucinous ovarian carcinomas.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Hollow发布了新的文献求助10
刚刚
qwaz完成签到,获得积分10
2秒前
2秒前
脑洞疼应助julien采纳,获得10
2秒前
852应助生医工小博采纳,获得10
3秒前
3秒前
喽喽完成签到,获得积分10
3秒前
叽里呱啦发布了新的文献求助10
3秒前
Ava应助Hollow采纳,获得10
6秒前
氮化硼小兵给氮化硼小兵的求助进行了留言
7秒前
10秒前
今后应助老乔采纳,获得10
12秒前
小蘑菇应助lunjianchi采纳,获得10
12秒前
刘佳冉完成签到,获得积分10
13秒前
13秒前
14秒前
淡然善斓完成签到,获得积分10
15秒前
要减肥的惜萱完成签到,获得积分10
16秒前
行路人发布了新的文献求助20
16秒前
整齐冬瓜完成签到,获得积分10
17秒前
xlxl发布了新的文献求助30
17秒前
Hello应助峰1992采纳,获得10
18秒前
19秒前
20秒前
Akim应助upsoar采纳,获得10
20秒前
20秒前
20秒前
LZQ应助wjw采纳,获得10
21秒前
FashionBoy应助孟古采纳,获得10
21秒前
科研通AI2S应助demian采纳,获得10
23秒前
踏雪飞鸿发布了新的文献求助10
24秒前
26秒前
27秒前
沈DJ发布了新的文献求助10
27秒前
spp完成签到 ,获得积分0
29秒前
31秒前
和谐的巨人完成签到 ,获得积分10
31秒前
重要鑫磊发布了新的文献求助10
33秒前
upsoar发布了新的文献求助10
36秒前
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3967419
求助须知:如何正确求助?哪些是违规求助? 3512730
关于积分的说明 11164792
捐赠科研通 3247704
什么是DOI,文献DOI怎么找? 1793978
邀请新用户注册赠送积分活动 874785
科研通“疑难数据库(出版商)”最低求助积分说明 804517