Wearable and implantable devices for drug delivery: Applications and challenges

医学 药物输送 药品 背景(考古学) 重症监护医学 可穿戴计算机 加药 生物医学工程 药理学 纳米技术 计算机科学 材料科学 生物 嵌入式系统 古生物学
作者
Abhinanda Kar,Nadim Ahamad,Mahima Dewani,Lisha Awasthi,Runali Patil,Rinti Banerjee
出处
期刊:Biomaterials [Elsevier BV]
卷期号:283: 121435-121435 被引量:80
标识
DOI:10.1016/j.biomaterials.2022.121435
摘要

Poor adherence to drug dosing schedule is responsible for ∼50% of hospitalization cases. Most patients fail to adhere to a strict dosing schedule due to invasive drug administration, off-target toxicities, or medical conditions like dementia. The emerging concept of wearable devices (WDs), implantable devices (IDs) and combined wearable and implantable devices (WIDs) for drug delivery has created new opportunities for treating patients with chronic diseases needing repeated and long-term medical attention like diabetes, ocular disorders, cancer, wound healing, cardiovascular diseases, and contraception. WDs, worn on the body surface have created appealing non-invasive, self-administrable drug delivery platforms which receive huge patient compliance. Microneedle-skin patches, wound healing patches, drug-eluting contact lenses, mouth guards, intra-vaginal rings, pharmaceutical jewelry, and drug-loaded self-care textiles are popular WDs explored in drug delivery. In contrast, IDs are surgically placed inside body tissue allowing higher payload and enhanced localized effect for an extended duration. Hormone micropumps, hydrogel/nanofibrous depot, coronary stents, intravitreal devices, and intrauterine devices are some representative examples of IDs. In this review, we have described the past 10 years of research progress on drug-delivering WDs and IDs in the context of treating diseases that demand repeated and long-term medication, especially those affecting soft tissues. We highlighted several technical challenges that need to be addressed before considering the translation of such technologies to clinics.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
1秒前
玥越完成签到,获得积分10
1秒前
dm11完成签到 ,获得积分10
2秒前
Akim应助靖123456采纳,获得10
3秒前
yizhe完成签到,获得积分10
3秒前
畅畅完成签到 ,获得积分10
3秒前
ChatGPT发布了新的文献求助10
4秒前
李健的小迷弟应助la采纳,获得10
4秒前
ZYN完成签到 ,获得积分10
5秒前
Mason完成签到,获得积分10
6秒前
yizhe发布了新的文献求助10
6秒前
JamesPei应助zzzz采纳,获得10
7秒前
英俊的铭应助aa采纳,获得30
7秒前
xiaohuhuan完成签到,获得积分10
7秒前
bulingbuling完成签到 ,获得积分10
8秒前
一颗小纽扣完成签到,获得积分10
9秒前
席涑完成签到,获得积分10
10秒前
CipherSage应助拼搏的婷冉采纳,获得10
10秒前
luoluo完成签到 ,获得积分10
11秒前
11秒前
醋炒栗子仁完成签到,获得积分10
11秒前
墨尔根戴青完成签到,获得积分10
12秒前
瑾瑜完成签到,获得积分10
13秒前
文小杰完成签到,获得积分10
13秒前
山月完成签到,获得积分10
14秒前
CodeCraft应助研友_LOK59L采纳,获得10
14秒前
14秒前
15秒前
欣慰妙海完成签到 ,获得积分20
15秒前
CodeCraft应助zhaopeipei采纳,获得10
15秒前
LIUYONG发布了新的文献求助10
16秒前
lin发布了新的文献求助10
18秒前
19秒前
九湖夷上完成签到 ,获得积分10
19秒前
噼里啪啦完成签到 ,获得积分10
20秒前
大个应助hahaha123213123采纳,获得30
20秒前
20秒前
惊天大幂幂完成签到,获得积分10
20秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029