An Open Port Sampling Interface for the Chemical Characterization of Levitated Microparticles

化学 电离 质谱法 分析物 环境电离 电喷雾电离 分析化学(期刊) 化学电离 色谱法 离子 有机化学
作者
Ravleen Kaur Kohli,Gary J. Van Berkel,James F. Davies
出处
期刊:Analytical Chemistry [American Chemical Society]
卷期号:94 (8): 3441-3445 被引量:20
标识
DOI:10.1021/acs.analchem.1c05550
摘要

Several studies have reported ionization methods to classify the chemical composition of levitated particles held in an electrodynamic balance using mass spectrometry (MS). These methods include electrospray-based paper spray (PS) ionization, plasma discharge ionization, and direct analysis in real-time (DART) ionization, with each showing advantages and disadvantages. Our recent work demonstrated that PS ionization could yield accurate data for the chemical evolution of mixed component particles undergoing evaporation. However, measurements were performed using an internal standard to account for and correct the inherent variability in the PS ionization source. Here, we explore a new electrospray-based method coupled to particle levitation–the Open Port Sampling Interface (OPSI), which provides many advantages over the PS method, with few disadvantages. In this application note we report experiments in which micron-sized particles, containing analytes such as citric acid, maleic acid, and tetraethylene glycol, were levitated and optically probed to determine their size and mass. Subsequent transfer of individual levitated particles into the OPSI allowed for the ionization and mass spectrometry analysis of these particles. We discuss the stability and reproducibility of MS measurements, demonstrate effective quantitation in both positive and negative mode, and determine the sensitivity of the OPSI to a range of analyte mass present in levitated particles. Importantly, we show stability of the OPSI over >6 h without the need for normalizing signal variations with an internal standard in the sample, demonstrating robust application of the OPSI to measurements over extended periods of time.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
亿一完成签到 ,获得积分10
1秒前
2秒前
2秒前
Lucas应助lsh采纳,获得10
2秒前
小程同学发布了新的文献求助10
2秒前
for_abSCI发布了新的文献求助10
3秒前
5秒前
6秒前
angin发布了新的文献求助30
7秒前
小何同学完成签到,获得积分10
10秒前
英俊的铭应助大意的以冬采纳,获得10
10秒前
共享精神应助AH106采纳,获得10
12秒前
冷静晓刚发布了新的文献求助10
13秒前
在水一方应助科研民工采纳,获得10
14秒前
15秒前
健康的修洁完成签到 ,获得积分10
16秒前
艾希发布了新的文献求助10
19秒前
王电催化发布了新的文献求助10
19秒前
20秒前
爱雪的猫完成签到,获得积分10
21秒前
宿刚完成签到,获得积分10
21秒前
程小柒完成签到 ,获得积分10
21秒前
善学以致用应助付品聪采纳,获得10
23秒前
24秒前
24秒前
angin完成签到,获得积分10
25秒前
25秒前
丘比特应助艾希采纳,获得10
26秒前
流草林完成签到,获得积分10
26秒前
27秒前
尛瞐慶成发布了新的文献求助10
27秒前
Aurora完成签到,获得积分10
27秒前
今后应助热心的思天采纳,获得10
28秒前
29秒前
傅觉然完成签到,获得积分10
29秒前
123发布了新的文献求助10
30秒前
Evan完成签到 ,获得积分10
30秒前
123关注了科研通微信公众号
30秒前
脑洞疼应助舒适书包采纳,获得10
31秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Fundamentals of Dispersed Multiphase Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3254080
求助须知:如何正确求助?哪些是违规求助? 2896443
关于积分的说明 8292655
捐赠科研通 2565288
什么是DOI,文献DOI怎么找? 1392945
科研通“疑难数据库(出版商)”最低求助积分说明 652418
邀请新用户注册赠送积分活动 629856