心肌梗塞
心功能曲线
心脏纤维化
心室重构
心脏病学
内科学
纤维化
医学
体内
细胞凋亡
梗塞
化学
心力衰竭
生物
生物化学
生物技术
作者
Bin Wang,Chengfan Wu,Shufang He,Yaguang Wang,Di Wang,Hui Tao,Chenchen Wang,Xiaoxi Pang,Fei Li,Yue Yuan,Eric R. Gross,Gaolin Liang,Ye Zhang
标识
DOI:10.1016/j.cej.2021.134450
摘要
Myocardial infarction (MI) is a major cause of disability and mortality worldwide. A cell permeable peptide V1-Cal has shown remarkable therapeutic effects on ML However, using V1-Cal to improve long-term cardiac function after MI is presently limited by its short half-life. Herein, we co-assembled V1-Cal with a well-known hydrogelator Nap-Phe-Phe-Tyr (NapFFY) to obtain a new supramolecular hydrogel V1-Cal/NapFFY. We found that the hydrogel could significantly enhance the therapeutic effects of V1-Cal on ventricular remodeling reduction and cardiac function improvement in a myocardial infarction rat model. In vitro experiments indicated that co-assembly of V1-Cal with NapFFY significantly increased mechanic strength of the hydrogel, enabling a sustained release of V1-Cal for more than two weeks. In vivo experiments supported that sustained release of V1-Cal from V1-Cal/NapFFY hydrogel could effectively decrease the expression and activation of TRPV1, reduce apoptosis and the release of inflammatory factors in a MI rat model. In particular, V1-Cal/NapFFY hydrogel significantly decreased infarct size and fibrosis, while improved cardiac function 28 days post MI. We anticipate that V1-Cal/NapFFY hydrogel could be used clinically to treat MI in the near future.
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