癌症研究
生物
体内
磷酸二酯酶
染色质
胶质母细胞瘤
干细胞
计算生物学
细胞生物学
遗传学
基因
酶
生物化学
作者
Deobrat Dixit,Briana C. Prager,Ryan C. Gimple,Tyler E. Miller,Qiulian Wu,Shira Yomtoubian,Reilly L. Kidwell,Deguan Lv,Linjie Zhao,Zhixin Qiu,Guoxin Zhang,Derrick Lee,Donglim Esther Park,Robert J. Wechsler‐Reya,Xiuxing Wang,Shideng Bao,Jeremy Rich
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2022-01-05
卷期号:14 (626)
被引量:15
标识
DOI:10.1126/scitranslmed.abf3917
摘要
DPY30 is an in vivo–specific dependency in glioblastoma that regulates phosphodiesterases and angiogenesis in the hypoxic tumor microenvironment.
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