Allergic contact dermatitis to phenoxyethanol – a rare, but possible cause of hand dermatitis

皮肤病科 接触性皮炎 医学 过敏性接触性皮炎 化妆品 过敏 手部皮炎 外科 免疫学 病理
作者
Michaela Kolodziej,Alexander Kiewert,Christoph Skudlik,Richard Brans
出处
期刊:Contact Dermatitis [Wiley]
卷期号:86 (4): 319-320 被引量:3
标识
DOI:10.1111/cod.14029
摘要

Phenoxyethanol (PE; Syn. 2-Phenyoxethanol; CAS no. 122-99-6) is one of the most commonly used preservatives in cosmetics and is also found in industrial products, including metalworking fluids. It is considered to have a low sensitization potential.1-3 A 59-year-old male toolmaker presented with therapy-resistant, 1-year lasting hand dermatitis suspected to be of occupational origin. Despite being on work leave and treatment with alitretinoin for the past 5 months, severe dermatitis of hands and lower arms was observed (Figure 1). We performed patch tests and readings according to the guidelines of the German Contact Dermatitis Research Group (DKG)4 using the DKG baseline series; the DKG series for topical preparations, preservatives, rubber, disinfectants, acrylates, industrial biocides, and metalworking fluids; and the patient's own metalworking fluid. Patch tests were removed at day (D) 2 with the exception of the metalworking fluid, which was removed already at D1 and reactions were evaluated at D2, D3, D4, and D7. Solely, a 2+ reaction to PE 1% pet. (SmartPractice, Greven, Germany) from D2 to D7 was noted (Figure 2A). PE was not found in any of the available safety datasheets of the patient's workplace products, including the metalworking fluid. However, according to the product labels, it was an ingredient of the patient's skin care products "Eucerin UreaRepair PLUS 5% Hand Creme" and "Nivea 3IN1 Repair Hand Creme" (both from Beiersdorf AG, Hamburg, Germany), which he had regularly applied on his hands and lower arms after the onset of dermatitis. Repeated open application test (ROAT) with "Eucerin UreaRepair PLUS 5% Hand Creme," two times daily for 6 days on the inner sides of the patient's upper arm resulted in a positive reaction (Figure 2B). Dermatitis of hands and lower arms improved significantly after avoidance of these skin care products, indicating clinical relevance of the sensitization to PE as the contributing factor to the initially occupational irritant contact dermatitis. Despite its widespread use as preservative in cosmetic and pharmaceutical products as well as for other applications, only very few cases of allergic contact dermatitis and contact urticaria to PE have been reported.2, 5-7 Accordingly, a retrospective study of the Information Network of Departments of Dermatology (IVDK) revealed a very low sensitization rate of 0.24% among 6932 individuals patch tested in Germany, Austria, and Switzerland between 1996 and 2009.1 Similarly, in 681 cutting metalworkers patch tested with the DKG metalworking fluids series in IVDK centres from 2010 to 2018, sensitization to PE was rarely observed (0.3%).8 Although rare, allergic contact dermatitis to PE should be considered and if undiscovered may lead to longstanding disease and inefficient treatments. The present case illustrates the importance of performing early patch tests to avoid delays in diagnosis and prevention measures. Diagnostic workup of patients with suspected occupational hand dermatitis should include patch testing and in doubtful cases also ROAT with patient's own skin care products. The authors declare no conflicts of interest. Michaela Kolodziej: Conceptualization (equal); investigation (equal); writing – original draft (equal); writing – review and editing (equal). Alexander Kiewert: Investigation (supporting); writing – review and editing (equal). Christoph Skudlik: Investigation (supporting); writing – review and editing (equal). Richard Brans: Conceptualization (equal); investigation (equal); supervision (lead); writing – original draft (equal); writing – review and editing (equal).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lalaland完成签到,获得积分10
刚刚
在水一方应助asd采纳,获得10
1秒前
johnnwick发布了新的文献求助10
1秒前
欣慰的星月完成签到,获得积分10
1秒前
我是老大应助jituher采纳,获得10
2秒前
JamesPei应助药小博采纳,获得10
2秒前
小刘恨香菜完成签到,获得积分10
2秒前
勿忸发布了新的文献求助10
3秒前
松松小白完成签到,获得积分10
3秒前
Cc关注了科研通微信公众号
3秒前
4秒前
4秒前
杰柒发布了新的文献求助10
4秒前
yc发布了新的文献求助10
4秒前
111舒舒完成签到 ,获得积分10
5秒前
Felix发布了新的文献求助10
5秒前
仄9发布了新的文献求助10
6秒前
6秒前
人福药业完成签到,获得积分10
6秒前
长生的落叶完成签到,获得积分10
7秒前
ljxx发布了新的文献求助10
7秒前
yznfly应助帅帅采纳,获得30
7秒前
之乡坞发布了新的文献求助500
8秒前
8秒前
李白白白完成签到,获得积分10
9秒前
9秒前
汉堡包应助ladette采纳,获得10
9秒前
9秒前
10秒前
拼搏听寒发布了新的文献求助10
10秒前
上官若男应助YU采纳,获得10
10秒前
顾矜应助o30采纳,获得10
10秒前
LLL完成签到,获得积分10
10秒前
11秒前
11秒前
11秒前
1111应助缪绯采纳,获得10
12秒前
12秒前
琪琪的发布了新的文献求助10
12秒前
十六完成签到,获得积分10
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969383
求助须知:如何正确求助?哪些是违规求助? 3514211
关于积分的说明 11172730
捐赠科研通 3249476
什么是DOI,文献DOI怎么找? 1794909
邀请新用户注册赠送积分活动 875441
科研通“疑难数据库(出版商)”最低求助积分说明 804827