化学
电泳剂
烯丙基重排
硅烷化
酮
烷基
部分
催化作用
三氟甲基
偶联反应
药物化学
有机化学
组合化学
作者
Haiyan Dong,Zhiyang Lin,Chuan Wang
标识
DOI:10.1021/acs.joc.1c02674
摘要
Herein we demonstrate the first successful application of cycloalkyl silyl peroxides (CSP) as an electrophilic coupling partner in the cross-electrophile coupling reaction. Diverse CSP are efficiently cross-coupled with an array of α-trifluoromethyl alkenes under the catalysis of nickel with the assistance of zinc as the reducing agent. This method allows the use of unstrained CSP as the carbonyl-containing alkyl source in the allylic defluorinative reaction, to access a variety of gem-difluoroalkenes bearing a pendent ketone moiety with high functionality tolerance.
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