红树林
内酯
化学
立体化学
质谱法
真菌
曲霉
植物
生物
色谱法
生态学
作者
Wenxiu Zhang,Lili Hao,Xiaoya Qin,Jiguo Huang,Rui‐Yun Yang,Jun Li,Xishan Huang
标识
DOI:10.1080/14786419.2021.1977298
摘要
A new lactone, asperlactone A (1), and four known lactone derivatives 2-5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. Their structures were elucidated based on high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of 1 was established. Compounds 1-5 were evaluated for their anti-inflammatory activities against nitric oxide (NO) production, and compounds 1-5 showed moderate inhibitory activities with IC50 values ranging from 15.87 to 30.48 µM.
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