Redefining the importance of polylactide-co-glycolide acid (PLGA) in drug delivery

PLGA公司 药物输送 可生物降解聚合物 纳米技术 生物相容性 自愈水凝胶 材料科学 生物医学工程 聚合物 医学 纳米颗粒 复合材料 高分子化学 冶金
作者
Yashashri R. Chavan,Srushti Tambe,Divya Jain,Sakshi V. Khairnar,Purnima D. Amin
出处
期刊:Annales pharmaceutiques françaises [Elsevier BV]
卷期号:80 (5): 603-616 被引量:11
标识
DOI:10.1016/j.pharma.2021.11.009
摘要

The limitations of non-biodegradable polymers have paved the way for biodegradable polymers in the pharmaceutical and biomedical sciences over the years. Poly (lactic-co-glycolic acid) (PLGA), also known as "Smart polymer", is one of the most successfully developed biodegradable polymers due to its favorable properties, such as biodegradability, biocompatibility, controllable drug release profile, and ability to alter surface with targeting agents for diagnosis and treatment. The release behavior of drugs from PLGA delivery devices is influenced by the physicochemical properties of PLGA. In this review, the current state of the art of PLGA, its synthesis, physicochemical properties, and degradation are discussed to enunciate the boundaries of future research in terms of its applicability with the optimized design in today's modern age. The fundamental objective of this review is to highlight the significance of PLGA as a polymer in the field of cancer, cardiovascular diseases, neurological disorders, dentistry, orthopedics, vaccine therapy, theranostics and lastly emerging epidemic diseases like COVID-19. Furthermore, the coverage of recent PLGA-based drug delivery systems including nanosystems, microsystems, scaffolds, hydrogels, etc. has been summarized. Overall, this review aims to disseminate the PLGA-driven revolution of the drug delivery arena in the pharmaceutical and biomedical industry and bridge the lacunae between material research, preclinical experimentation, and clinical reality.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
姚世娇完成签到 ,获得积分10
1秒前
FashionBoy应助高手采纳,获得10
2秒前
meng完成签到,获得积分10
3秒前
chennn完成签到,获得积分10
3秒前
5秒前
6秒前
晗月完成签到,获得积分10
6秒前
情怀应助如意枫叶采纳,获得10
7秒前
量子星尘发布了新的文献求助10
9秒前
Akim应助SS采纳,获得10
10秒前
张雷应助清新的夜蕾采纳,获得20
10秒前
chennn发布了新的文献求助10
10秒前
罗一完成签到,获得积分10
12秒前
14秒前
丘比特应助wu采纳,获得10
17秒前
俏皮芷蕊发布了新的文献求助30
17秒前
称心的菲鹰完成签到,获得积分10
18秒前
碧蓝问安发布了新的文献求助10
19秒前
19秒前
打打应助ZZZ采纳,获得10
21秒前
25秒前
呆萌板凳发布了新的文献求助10
25秒前
hp关闭了hp文献求助
26秒前
27秒前
都选C完成签到,获得积分10
28秒前
壮观以松完成签到,获得积分10
28秒前
Liufgui应助郭小宝采纳,获得20
28秒前
heli完成签到,获得积分10
30秒前
如意枫叶发布了新的文献求助10
31秒前
都选C发布了新的文献求助10
32秒前
英俊的铭应助淡烟流水采纳,获得10
33秒前
33秒前
Miracle完成签到,获得积分10
35秒前
39秒前
wu发布了新的文献求助10
39秒前
忧心的听双完成签到,获得积分10
39秒前
Timon完成签到,获得积分10
40秒前
深情安青应助Miracle采纳,获得10
41秒前
李健应助猪猪hero采纳,获得10
41秒前
kingwill应助Harlotte采纳,获得60
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136