Association betweenNFKB1−94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis

优势比 等位基因 荟萃分析 前列腺癌 遗传学 内科学 肿瘤科 发病机制 遗传模型 置信区间 癌症 医学 生物 生物信息学 基因
作者
Xiao Yang,Pengchao Li,Jun Tao,Chao Qin,Qiang Cao,Jingyu Gu,Xiaheng Deng,Jun Wang,Xuzhong Liu,Zijie Wang,Bian Wu,Min Gu,Qiang Lü,Yin Chen
出处
期刊:International journal of genomics [Hindawi Publishing Corporation]
卷期号:2014: 1-8 被引量:23
标识
DOI:10.1155/2014/612972
摘要

Nuclear factor- κ B is associated with the pathogenesis of numerous malignancies, and the functional polymorphism −94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk. Previous studies on the association between the −94ins/del ATTG polymorphism and cancer risk reported conflicting results. To clarify this relationship, we performed a meta-analysis of 21 case-control studies involving 6127 cases and 9238 controls. We used pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs) to assess the association. We found that the NFKB1 promoter −94ins/del ATTG polymorphism was significantly associated with cancer risk in four genetic models (ins/ins versus del/del, OR = 1.47, 95% CI = 1.11–1.93; dominant model, OR = 1.26, 95% CI = 1.03–1.53; recessive model, OR = 1.26, 95% CI = 1.05–1.51; ins allele versus del allele, OR = 1.19, 95% CI = 1.05–1.35). Stratified analyses revealed a significant association between the polymorphism and ovarian, oral, and prostate cancers. Similar results were determined in an Asian population and not in a Caucasian population. Thus, our results suggested that the polymorphism can contribute to cancer risk. Moreover, the polymorphism can exert race- and cancer-specific effects on cancer risk. Further large-scale and functional studies are necessary to elucidate this possible effect.

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