肺癌
医学
内科学
基因型
优势比
人口
肿瘤科
胃肠病学
等位基因
肺癌易感性
置信区间
癌症
单核苷酸多态性
病例对照研究
多态性(计算机科学)
危险系数
中国人口
基因多态性
作者
Xin Hou,Yuhua Gao,Yongjian Duan,Zhiwei Wang,Lei Shi,Jincheng Ma,Xuanhu Xie
标识
DOI:10.4103/0973-1482.163854
摘要
Objective: The association between the myeloperoxidase (MPO) 463 G>A polymorphism and lung cancer risk remains controversial. We perform this meta-analysis to further evaluate the MPO 463G>A polymorphism and lung cancer susceptibility. Materials and Methods: We performed the systemic literature search in PubMed, EMBASE, WANFANG, and CNKI databases for molecular epidemiologic studies on the association of MPO 463G>A polymorphism and lung cancer susceptibility. The pooled odds ratio (OR) of MPO 463G>A polymorphism and lung cancer risk were calculated by random or fixed effect model. Results: Seven case-control studies including 1538 lung cancer patients in the case group and 1673 healthy controls in the control group were included in this study. MPO 463G>A polymorphism was not associated with lung cancer susceptibility under the condition of recessive genetic model (AA vs. GG+GA) (OR = 0.69, P > 0.05) and homozygous genetic model (AA vs. GG) (OR = 0.65, P > 0.05). However, we found significantly decreased risk of lung cancer under dominant genetic model (GA+AA vs. GG) (OR = 0.84, P 0.05). Conclusion: This meta-analysis indicated that people with AA genetic type may have decreased lung cancer risk under dominant genetic model.
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