髓系白血病
细胞培养
永生化细胞系
血液学
癌症研究
髓样
白血病
核型
肿瘤科
医学
生物
计算生物学
生物信息学
内科学
遗传学
染色体
基因
作者
Rafał Skopek,Małgorzata Palusińska,Katarzyna Barbara Kaczor-Keller,Rafał Pingwara,Anna Papierniak,Tino Schenk,Sławomir Lewicki,Artur Zelent,Łukasz Szymański
摘要
Immortalized cell lines are widely used in vitro tools in oncology and hematology research. While these cell lines represent artificial systems and may accumulate genetic aberrations with each passage, they are still considered valuable models for pilot, preliminary, and screening studies. Despite their limitations, cell lines are cost-effective and provide repeatable and comparable results. Choosing the appropriate cell line for acute myeloid leukemia (AML) research is crucial for obtaining reliable and relevant results. Several factors should be considered when selecting a cell line for AML research, such as specific markers and genetic abnormalities associated with different subtypes of AML. It is also essential to evaluate the karyotype and mutational profile of the cell line, as these can influence the behavior and response to the treatment of the cells. In this review, we evaluate immortalized AML cell lines and discuss the issues surrounding them concerning the revised World Health Organization and the French–American–British classifications.
科研通智能强力驱动
Strongly Powered by AbleSci AI