亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography

子宫输卵管造影术 甲状腺功能不全 对比度(视觉) 医学 甲状腺 产科 妇科 内科学 化学 怀孕 物理 不育 生物 有机化学 光学 遗传学
作者
Divya M. Mathews,Jane Peart,Robert G. Sim,Neil P. Johnson,Susannah O’Sullivan,José G. B. Derraik,Paul L. Hofman
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [The Endocrine Society]
卷期号:107 (12): 3252-3260 被引量:16
标识
DOI:10.1210/clinem/dgac546
摘要

Hysterosalpingography (HSG) with oil-soluble contrast medium (OSCM) improves pregnancy rates. However, OSCM has high iodine content and long half-life, leading to potential iodine excess.This work aimed to determine the pattern of iodine excess after OSCM HSG and the effect on thyroid function.A prospective cohort study was conducted of 196 consecutive consenting eligible women without overt hypothyroidism or hyperthyroidism. All completed the study with compliance greater than 95%. Participants underwent OSCM HSG (Auckland, 2019-2021) with serial monitoring of thyrotropin (TSH), free thyroxine (FT4), and urine iodine concentration (UIC) for 24 weeks. The main outcome measure was the development of subclinical hypothyroidism (SCH), defined as a nonpregnant TSH greater than 4 mIU/L with normal FT4 (11-22 pmol/L) in those with normal baseline thyroid function.Iodine excess (UIC ≥ 300 μg/L) was almost universal (98%) with UIC peaking usually by 4 weeks. There was marked iodine excess, with 90% and 17% of participants having UIC greater than or equal to 1000 μg/L and greater than 10 000 μg/L, respectively. Iodine excess was prolonged with 67% having a UIC greater than or equal to 1000 μg/L for at least 3 months. SCH developed in 38%; the majority (96%) were mild (TSH 4-10 mIU/L) and most developed SCH by week 4 (75%). Three participants met the current treatment guidelines (TSH > 10 mIU/L). Thyroxine treatment of mild SCH tended to improve pregnancy success (P = .063). Hyperthyroidism (TSH < 0.3 mIU/L) occurred in 9 participants (5%).OSCM HSG resulted in marked and prolonged iodine excess. SCH occurred frequently with late-onset hyperthyroidism occasionally. Regular thyroid function tests are required for 6 months following this procedure.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
郑夏岚完成签到,获得积分20
1秒前
白日焰火完成签到 ,获得积分10
2秒前
16秒前
charliechen完成签到 ,获得积分10
16秒前
可爱的函函应助复印件采纳,获得10
19秒前
予秋发布了新的文献求助10
20秒前
34秒前
pan123456发布了新的文献求助30
44秒前
pan123456完成签到,获得积分10
1分钟前
Leo完成签到 ,获得积分10
1分钟前
2分钟前
爱静静应助科研通管家采纳,获得10
2分钟前
然后发布了新的文献求助10
2分钟前
2分钟前
大脸猫完成签到 ,获得积分10
2分钟前
NexusExplorer应助fredericev采纳,获得10
2分钟前
复印件发布了新的文献求助10
2分钟前
华仔应助然后采纳,获得10
3分钟前
3分钟前
3分钟前
Jun完成签到 ,获得积分10
3分钟前
fredericev发布了新的文献求助10
3分钟前
3分钟前
复印件完成签到,获得积分10
3分钟前
4分钟前
joanna完成签到,获得积分10
4分钟前
4分钟前
爱静静应助科研通管家采纳,获得10
4分钟前
4分钟前
拓跋从阳完成签到,获得积分10
4分钟前
拓跋从阳发布了新的文献求助10
4分钟前
4分钟前
5分钟前
6分钟前
Georgechan完成签到,获得积分10
6分钟前
下雨天完成签到 ,获得积分10
6分钟前
6分钟前
道消完成签到,获得积分10
6分钟前
7分钟前
7分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052527
求助须知:如何正确求助?哪些是违规求助? 2709785
关于积分的说明 7418181
捐赠科研通 2354355
什么是DOI,文献DOI怎么找? 1245897
科研通“疑难数据库(出版商)”最低求助积分说明 605927
版权声明 595908