光热治疗
材料科学
药物输送
纳米技术
生物相容性
纳米医学
生物物理学
纳米器件
药品
生物医学工程
癌症研究
纳米颗粒
药理学
生物
医学
冶金
作者
Yao‐Haur Kuo,Yao‐Haur Kuo,Yao‐Haur Kuo,Yao‐Haur Kuo,Yao‐Haur Kuo,Yao‐Haur Kuo,Yao‐Haur Kuo
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2024-06-21
卷期号:35 (36): 365703-365703
标识
DOI:10.1088/1361-6528/ad5690
摘要
Abstract Extracellular vesicles (EVs) have great potential in oncology drug delivery because of their unique biological origin. Apoptotic bodies (ABs), as a member of the EV family, offer distinct advantages in terms of size, availability and membrane properties, but have been neglected for a long time. Here, using ABs and Ti 2 N nanosheets, we propose a novel drug delivery system (Ti 2 N-DOX@ABs), which exhibit a homologous targeting ability for dual-strategy tumor therapy with intrinsic biological property. The experimental results demonstrate that such a drug delivery system possesses a drug loading capacity of 496.5% and a near-infrared photothermal conversion efficiency of 38.4%. In addition, the investigation of drug internalization process proved that Ti 2 N-DOX@ABs featured a supreme biocompatibility. Finally, the dual-strategy response based on photothermal and chemotherapeutic effects was studied under near-infrared laser radiation. This work explores the opportunity of apoptosome membranes in nanomedicine systems, which provides a technical reference for cancer-oriented precision medicine research.
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