Contributions of Coping Flexibility and Associated Functional Brain Connectivity to Resilient Trajectories of Mental Health During the COVID-19 Pandemic

The COVID-19 pandemic has presented an unprecedented challenge for individual mental health. In this study, we examined the lasting impact of the pandemic on mental health among Chinese college students and tested whether different coping dimensions contributed to resilience. Using a 2-year longitudinal design with four waves, we identified four common trajectories for individuals’ levels of depression and anxiety: resilient, recovered, delayed, and chronic. With prepandemic coping and resting-state neuroimaging data as predictors, we found that coping flexibility and corresponding connectivity patterns significantly predicted increased odds ratios of resilient trajectories for depression and anxiety. However, use of specific emotion-regulation strategies (i.e., cognitive reappraisal and expressive suppression) did not predict resilient trajectories. Overall, findings help to identify heterogeneity in emotional trajectories during the pandemic and indicate that coping flexibility plays a critical role in resilience. This work has implications for clinical-risk identification and developing mental-health interventions for the current pandemic and future crises.