细胞生物学
细胞生长
T细胞
IRF4公司
功能(生物学)
CD8型
细胞
生物
免疫系统
转录因子
免疫学
遗传学
基因
作者
Thibault Hirsch,Pierre van der Bruggen,Mathieu Luyckx,Mathieu Luyckx,Mathieu Luyckx,Mathieu Luyckx,Pierre van der Bruggen,Mathieu Luyckx,Pierre van der Bruggen,Mathieu Luyckx,Pierre van der Bruggen,Mathieu Luyckx,Pierre van der Bruggen
出处
期刊:Cell Reports
[Elsevier]
日期:2024-07-01
卷期号:43 (7): 114401-114401
标识
DOI:10.1016/j.celrep.2024.114401
摘要
Human CD8 tumor-infiltrating lymphocytes (TILs) with impaired effector functions and PD-1 expression are categorized as exhausted. However, the exhaustion-like features reported in TILs might stem from their activation rather than the consequence of T cell exhaustion itself. Using CRISPR-Cas9 and lentiviral overexpression in CD8 T cells from non-cancerous donors, we show that the T cell receptor (TCR)-induced transcription factor interferon regulatory factor 4 (IRF4) promotes cell proliferation and PD-1 expression and hampers effector functions and expression of nuclear factor κB (NF-κB)-regulated genes. While CD8 TILs with impaired interferon γ (IFNγ) production exhibit activation markers IRF4 and CD137 and exhaustion markers thymocyte selection associated high mobility group box (TOX) and PD-1, activated T cells in patients with COVID-19 do not demonstrate elevated levels of TOX and PD-1. These results confirm that IRF4
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