背景(考古学)
脑膜炎
纳米技术
药物输送
抗生素
医学
纳米医学
材料科学
纳米颗粒
生物
微生物学
外科
古生物学
作者
Dipanjan Karati,Swarupananda Mukherjee,Susmita Paul,Suchana Das,Bhupendra G. Prajapati,Ravish J. Patel,Sajal Kumar Jha
标识
DOI:10.2174/0113892010303028240429073144
摘要
Abstract: The meninges serve as a protective layer, and the fluid around the brain and spinal cord can become inflamed, known as meningitis. Lipid-based pharmaceutical formulations, by their high lipophilicity, can negotiate the Blood-Brain Barrier (BBB). The current mode of treatment of meningitis is mainly through antibiotics, which, at best, is partially effective. The success of antibiotic therapy depends on several factors, for example, the difficulty of reaching the infection site, maintaining proper concentrations of the drug after crossing the BBB, and finally, its efficacy in preventing recurrent infection. In this context, interest has focused on organic and inorganic nanostructures for meningitis and transporting antibiotics to the selected region through the BBB. A focus has also been placed on several polymeric nanotechnology techniques for detecting various types of meningitis. This review focuses on nano interventions and their most recent meningitis treatments using nanotechnology.
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