洗剂
医学
组胺
嘧啶二聚体
皮肤病科
紫外线a
无毛
人体皮肤
药理学
生物化学
DNA损伤
化学
遗传学
生物
DNA
作者
Joanna Wu,Jin Namkoong,Sayantani Goswami,Joel L. Cohen,Nadia A. Soliman
出处
期刊:Journal of Drugs in Dermatology
[SanovaWorks]
日期:2024-04-01
卷期号:23 (5): 366-375
摘要
Objective: This study aimed to investigate the ultraviolet (UV) protection/repair benefits of a patented Amino Acid Complex (AAComplex). Methods: I) AAComplex was incubated with dermal fibroblasts, with/without UVA, and collagen I was measured with a GlasBoxPlus device. II) A lotion, with/without AAComplex (1%) was applied topically to skin explants, following UVA irradiation, and quantified for health-related biomarkers (TNFalpha, histamine, and MMP-1). III) A broad spectrum sunscreen with SPF 46 and a skincare serum containing AAComplex (2%) were assessed using epidermal equivalents, in the presence of UV irradiation, for effects on IL-1alpha, thymine dimers, Ki-67, filaggrin and Nrf2.
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