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HomeCirculation ResearchVol. 134, No. 8AKAP12 Overexpression Affects Cardiac Function via PDE8 No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextAKAP12 Overexpression Affects Cardiac Function via PDE8 Hariharan Subramanian and Viacheslav O. Nikolaev Hariharan SubramanianHariharan Subramanian https://orcid.org/0000-0001-5409-4856 Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (H.S., V.O.N.). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (H.S., V.O.N.). and Viacheslav O. NikolaevViacheslav O. Nikolaev Correspondence to: Viacheslav O. Nikolaev, PhD, Institute of Experimental Cardiovascular Research, University Medical Center, Hamburg-Eppendorf Martinistr. 52, House W23, D-20246, Hamburg, Germany. Email E-mail Address: [email protected] https://orcid.org/0000-0002-7529-5179 Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (H.S., V.O.N.). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (H.S., V.O.N.). Originally published11 Apr 2024https://doi.org/10.1161/CIRCRESAHA.124.324475Circulation Research. 2024;134:1023–1025This article is a commentary on the followingAKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac DysfunctionFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 1025.Correspondence to: Viacheslav O. Nikolaev, PhD, Institute of Experimental Cardiovascular Research, University Medical Center, Hamburg-Eppendorf Martinistr. 52, House W23, D-20246, Hamburg, Germany. Email v.nikolaev@uke.deREFERENCES1. Subramanian H, Nikolaev VO. A-kinase anchoring proteins in cardiac myocytes and their roles in regulating calcium cycling.Cells. 2023; 12:436. doi: 10.3390/cells12030436CrossrefMedlineGoogle Scholar2. McConnell BK, Popovic Z, Mal N, Lee K, Bautista J, Forudi F, Schwartzman R, Jin JP, Penn M, Bond M. Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis.J Biol Chem. 2009; 284:1583–1592. doi: 10.1074/jbc.M806321200CrossrefMedlineGoogle Scholar3. Fink MA, Zakhary DR, Mackey JA, Desnoyer RW, Apperson-Hansen C, Damron DS, Bond M. 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Circulation Research. 2024;134:1006-1022 April 12, 2024Vol 134, Issue 8 Advertisement Article InformationMetrics © 2024 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.124.324475PMID: 38603476 Originally publishedApril 11, 2024 KeywordsEditorialshypertrophynucleotides, cyclicphosphorylationreceptors, adrenergic, beta3',5'-cyclic-AMP phosphodiesterasesPDF download Advertisement