Interaction between age and efficacy of dual antiplatelet therapy in non-cardioembolic minor acute ischemic stroke or high-risk transient ischemic attack

Short-term (21–90 days) dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel is recommended for patients with minor non-cardioembolic ischemic stroke [National Institutes of Health Stroke Scale (NIHSS) score ≤3] or high-risk transient ischemic attack (TIA) [Age, Blood Pressure, Clinical Features, Duration of TIA, Diabetes Mellitus (ABCD2) scale ≥4] [1,2]. Early initiation should be offered (ideally within 12–24 h of symptoms onset) and only to patients not receiving thrombolysis [1,2].