代谢组学
肠道菌群
疾病
消化道
肠-脑轴
胃肠道
生物
生物信息学
生物化学
医学
病理
内科学
作者
Na Li,Cheng Zhao,Pingnan Zhang,S. L. Wu,Xiaotan Dou,Saifei Xu,Xiaoqi Zhang,Chunyan Peng,Ying Xie,Shuling Huang,Lin Zhou,Yonghua Shen,Lei Wang,Jinglin Wang,Chenggong Yu
标识
DOI:10.1016/j.engreg.2024.04.003
摘要
The gut has been a focal point in the research of digestive system disorders. The internal microbiota generates metabolites that function as signaling molecules and substrates, interacting with the intestinal wall and influencing host physiology and pathology. Besides, the gut microbiota and metabolites owe highly diverse types and quantities, posing challenges for quantitative analysis, and monitoring frequent interactions between digestive tract metabolites and the intestinal wall remains a challenge. However, research targeting gut microbiota metabolites has elucidated their relevance to digestive diseases. By modulating metabolites such as short-chain fatty acids, bile acids, and lipopolysaccharides, it is possible to intervene in the progression of diseases such as inflammatory bowel disease and non-alcoholic fatty liver disease. Currently, research on gut microbiota is advancing, and more work is required to explore the interactions between host, microbes and underlying mechanisms. In this review, we have revisited the generation of gut microbiota-related metabolites, their impact on diseases, and modes of interaction, emphasizing the significant role of metabolites in digestive system disorders. It is believed that the linkage between gut microbiota and diseases in current research can be established through metabolites, providing a framework and foundation for research in the field of metabolomics and fundamental mechanisms.
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