68Ga-Labeled Fibroblast Activation Protein Inhibitor PET/CT for the Early and Late Prediction of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer Patients: A Prospective Study

医学 乳腺癌 核医学 化疗 成纤维细胞活化蛋白 原发性肿瘤 PET-CT 淋巴结 淋巴 前瞻性队列研究 免疫组织化学 癌症 病变 病理 正电子发射断层摄影术 内科学 转移
作者
Ling Chen,Shusen Zheng,Linying Chen,Sunwang Xu,Kunlin Wu,Lingjun Kong,Jiajie Xue,Xiangjin Chen,Weibing Miao,Youzhi Zhu
出处
期刊:The Journal of Nuclear Medicine [Society of Nuclear Medicine and Molecular Imaging]
卷期号:64 (12): 1899-1905 被引量:3
标识
DOI:10.2967/jnumed.123.266079
摘要

68Ga-labeled fibroblast activation protein inhibitor (68Ga-FAPI) PET/CT has demonstrated promising clinical results, with a higher SUVmax and tumor-to-background ratio (TBR) in breast cancer (BC) patients than 18F-FDG PET/CT. Here, we aimed to evaluate the suitability of 68Ga-FAPI PET/CT for the early and late prediction of the pathologic response to neoadjuvant chemotherapy (NAC) in BC. Methods: Twenty-two consecutive patients with newly diagnosed BC and an indication for NAC were prospectively included. All patients underwent standard chemotherapy and 68Ga-FAPI PET/CT at baseline, after 2 cycles of NAC (PET2), and 1 wk before surgery (PET3). SUVmax was measured in the primary tumor region and positive regional lymph nodes. The expression of fibroblast activation protein in the primary lesion was analyzed by immunohistochemistry. Results: Seven patients (31.8%) achieved a pathologic complete response (pCR), and 15 (68.2%) had residual tumors. Thirteen patients (59.1%) showed concentric withdrawal of the primary tumor, and 9 (40.9%) showed diffuse withdrawal. Between PET2 and PET3, the ΔSUVmax of the primary tumor (R2 = 0.822; P = 0.001) and metastatic lymph nodes (R2 = 0.645; P = 0.002) were significantly correlated. The absolute values of SUVmax and TBR at PET2 and PET3 were lower in patients with pCR than in those without pCR (P < 0.05). Moreover, a larger ΔSUVmax at any time point was strongly associated with pCR (P < 0.05). Similar downward trends in SUVmax, TBR, and ΔSUVmax were observed in the pattern of primary tumor reduction. For predicting pCR, the optimal cutoff values for ΔSUVmax after 2 chemotherapy cycles, ΔSUVmax before surgery, TBR after 2 chemotherapy cycles, and TBR before surgery of the primary tumor were 3.4 (area under the curve [AUC], 0.890), 1.1 (AUC, 0.978), -63.8% (AUC, 0.879), -90.8% (AUC, 0.978), 7.6 (AUC, 0.848), and 1.4 (AUC, 0.971), respectively. Immunohistochemistry showed that the SUVmax and TBR of 68Ga-FAPI PET/CT were positively correlated with fibroblast activation protein expression (P < 0.001 for both). Conclusion: Assessment of early changes in 68Ga-FAPI uptake during NAC by 68Ga-FAPI PET/CT can predict pCR and primary tumor concentric withdrawal in BC patients. 68Ga-FAPI PET/CT has great potential for the early and late prediction of the pathologic response to NAC in BC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助emm采纳,获得10
刚刚
刚刚
Tina完成签到 ,获得积分10
刚刚
羞涩的文轩完成签到,获得积分10
刚刚
1秒前
丞123完成签到,获得积分10
1秒前
清风完成签到,获得积分10
1秒前
烟花应助鱼生采纳,获得10
1秒前
2秒前
phoenix完成签到,获得积分20
2秒前
2秒前
2秒前
郭guoguo完成签到,获得积分10
3秒前
4秒前
汪汪发布了新的文献求助10
4秒前
4秒前
4秒前
小电风扇完成签到,获得积分10
4秒前
oak完成签到,获得积分10
5秒前
wanci应助GLN采纳,获得10
5秒前
5秒前
马婷婷发布了新的文献求助10
5秒前
孩子气发布了新的文献求助10
6秒前
xielixin2001完成签到,获得积分10
6秒前
6秒前
bkagyin应助张火火采纳,获得10
6秒前
7秒前
战战发布了新的文献求助10
7秒前
emm发布了新的文献求助10
7秒前
7秒前
8秒前
xuexi完成签到,获得积分10
8秒前
包子发布了新的文献求助10
8秒前
8秒前
孝陵卫黑旋风完成签到,获得积分10
8秒前
卢飞薇发布了新的文献求助10
8秒前
9秒前
xuxu完成签到 ,获得积分10
9秒前
Lucas应助唯有言若采纳,获得10
9秒前
笑点低的远望完成签到,获得积分10
9秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969060
求助须知:如何正确求助?哪些是违规求助? 3513962
关于积分的说明 11171223
捐赠科研通 3249302
什么是DOI,文献DOI怎么找? 1794772
邀请新用户注册赠送积分活动 875377
科研通“疑难数据库(出版商)”最低求助积分说明 804769