Haematological and other manifestions in the presence of antiphospholipid antibodies in a multicentric paediatric cohort

医学 队列 抗磷脂综合征 内科学 回顾性队列研究 单变量分析 狼疮抗凝剂 胃肠病学 比例危险模型 血液学 免疫学 儿科 血栓形成 多元分析
作者
Patrícia Álvarez,Á. Andreu-Suárez,Liz Caballero-Mota,Sussana Gassiot-Riu,Rubén Berrueco-Moreno,Joan Calzada-Hernández,Mónica Vázquez-Díaz,Alina Boteanu,Virginia Messia,Luigi Giovannelli,Fabrizio De Benedetti,Jordi Antón-López,Claudia Bracaglia
出处
期刊:Clinical and Experimental Rheumatology [Springer Vienna]
标识
DOI:10.55563/clinexprheumatol/3mzh06
摘要

To identify the variables associated with the development of haematological manifestations in the presence of antiphospholipid antibodies (aPLs) in a paediatric cohort.We conducted a multicentric retrospective cohort study of children under the age of 18 years.One hundred and thirty-four children were included; 12.2% had at least one thrombotic event (TE) and 67% at least one non-criterion manifestation. Of them, 90% did not develop any TE. Haematological manifestations were the most frequent (42%), followed by neurological (19.8%), cutaneous (17.6%), cardiac (16.8%) and renal (1.5%) manifestations. In those children with haematological disorders, the aPLs positivity rate was: 67.3% LA, 65.6% aβ2GPI, 60% aCL, 45.5% single, 23.6% double and 30.9% triple. A univariate analysis showed that children with IgM aCL+, IgM aβ2GPI+, triple positivity and with a SLE diagnosis had a significantly higher frequency of haematological manifestations (p<0.05). Finally, a stepwise regression analysis identified IgG aβ2GPI positivity [OR 2.91, 95% CI (1.26-6.74), p=0.013], SLE [OR 2.67, 95% CI (1.13-6.3), p=0.026] and LA positivity [OR 2.53, 95% CI (1.08-5.94), p=0.033] as independent risk factors for the development of haematological manifestations.Non-criteria manifestations and among them haematological disorders, are the most frequent events in the presence of aPLs and/or LA in our paediatric cohort. Children with SLE, LA and/or IgG aβ2GPI positivity showed a higher risk of haematological manifestations.
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